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1.
National Journal of Andrology ; (12): 255-258, 2008.
Article Dans Chinois | WPRIM | ID: wpr-319232

Résumé

<p><b>OBJECTIVE</b>To investigate the clinical and pathological characteristics, treatment and prognosis of peripheral primitive neuroectodermal tumor (PNET) of the urinary tract and reproductive system.</p><p><b>METHODS</b>The clinical data and pathological characteristics of a PNET patient was analyzed and relevant literature reviewed.</p><p><b>RESULTS</b>The diagnosis was established by pathological and immunohistochemical method. The patient underwent radical surgery, followed by chemotherapy.</p><p><b>CONCLUSION</b>Pathology and immunohistochemistry help the diagnosis of PNET. For the treatment of the tumors in the early stage, surgery is the best choice, and for that in the late stage, it can be followed by chemotherapy. The PNET of the penis is a rare disease and evidence still lacks for the evaluation of its prognosis.</p>


Sujets)
Sujet âgé , Humains , Mâle , Antigène CD99 , Antigènes CD , Molécules d'adhérence cellulaire , Association thérapeutique , Immunohistochimie , Tumeurs neuroectodermiques primitives , Diagnostic , Métabolisme , Thérapeutique , Tumeurs du pénis , Diagnostic , Métabolisme , Thérapeutique , Enolase , Pronostic
2.
Chinese Journal of Medical Genetics ; (6): 192-194, 2006.
Article Dans Chinois | WPRIM | ID: wpr-263820

Résumé

<p><b>OBJECTIVE</b>To study the gene mutation of collagen, type I, alpha 1 (COL1A1) associated with the clinical characterization of a Chinese family with type I osteogenesis imperfecta (OI).</p><p><b>METHODS</b>Polymerase chain reaction, DNA sequencing and restriction endonuclaese analysis were used to check all the members in the family with OI and 50 normal control people for detecting the mutation of COL1A1 gene.</p><p><b>RESULTS</b>A 2461G>A (G821S) mutation was found and identified in COL1A1 gene of OI patients, to whom the individual clinical characterization was displayed, however. And the other members in the family with OI and the control did not have such gene mutation as 2461G>A.</p><p><b>CONCLUSION</b>The mutation of COL1A1 gene is one of the OI etiologic causes in China. There is no simple universal linkage between such gene changes and OI phenotype, but which not only involved in the OI genotype but the genetic background as well.</p>


Sujets)
Humains , Asiatiques , Génétique , Séquence nucléotidique , Chine , Collagène de type I , Génétique , Analyse de mutations d'ADN , Mutation , Ostéogenèse imparfaite , Génétique , Pedigree
3.
Chinese Journal of Plastic Surgery ; (6): 194-196, 2005.
Article Dans Chinois | WPRIM | ID: wpr-255075

Résumé

<p><b>OBJECTIVE</b>To observe the changes in histopathology and clinical effect after the treatment of superficial scars in human faces and exposed parts of human extremities with crystallitic dermabrasion.</p><p><b>METHODS</b>The machine made in Italy can produce the high speed crystallite to the surface of the scar, resulting in the alveolate wounds. At the same time the crystallitic drill make the accidental scar smooth.</p><p><b>RESULTS</b>Two thousands and five hundreds and thirty eight suffers were treated for 2-10 times. The appearance of the scars was improved. Six patients complicated with milium, Eleven got hypopigmentation, eight got hypomelanotation. Eighty percent patients of this groups got pigmentation after the treatment. This signs disappeared or improved after 2-6 months. Histopathology demonstrated the scar area became small, the fibroblasts increased remarkably and the collagenous fiber arranged regularly. The cells in the stratum spinosum proliferated actively.</p><p><b>CONCLUSIONS</b>Crystallitic dermabrasion is a simple and safe method for the treatment of skin superficial scars.</p>


Sujets)
Adolescent , Adulte , Sujet âgé , Enfant , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Cicatrice , Chirurgie générale , Dermabrasion , Méthodes , Hyperpigmentation , Chirurgie générale
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