Résumé
An unusual novel C27-steroidal glycoside sulfate was isolated from the underground organs of Liriope graminifolia (Linn.) Baker with three known compounds. Their chemical structures were determined by spectral analysis, including HR-MS, 1D and 2D NMR as (25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside (1), (25S)-ruscogenin 1-O-beta-D-xylopyranosyl-3-O-alpha-L-rhamnopyranoside (2), hesperidin (3), and 4', 7-dihydroxy-5-methoxyflavanone (4). Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively.
Sujets)
Humains , Antinéoplasiques d'origine végétale , Chimie , Pharmacologie , Prolifération cellulaire , Médicaments issus de plantes chinoises , Chimie , Pharmacologie , Hétérosides , Chimie , Pharmacologie , Cellules HL-60 , Hespéridine , Chimie , Pharmacologie , Concentration inhibitrice 50 , Cellules K562 , Liriope , Chimie , Tubercules , Chimie , Plantes médicinales , Chimie , Spirostanes , Chimie , PharmacologieRésumé
<p><b>OBJECTIVE</b>To study the chemical constituents of Microtropis triflora.</p><p><b>METHOD</b>The compounds were isolated by chromatography on silica gel and Sephadex LH-20. There structures were elucidatedby by chemical methods and spectral analysis.</p><p><b>RESULT</b>Five triterpenoids were isolated and elucidated as friedelin (1), 3-oxo-28-friedelanoic acid (2), 29-hydroxy-3-friedelanone (3), salaspermic acid (4), orthosphenic acid (5).</p><p><b>CONCLUSION</b>Compounds 1-5 are all isolated from M. triflora for the first time.</p>