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1.
Chinese Journal of Oncology ; (12): 747-750, 2013.
Article Dans Chinois | WPRIM | ID: wpr-267464

Résumé

<p><b>OBJECTIVE</b>To investigate the correlation of baseline plasma D-dimer levels and clinicopathological features and tumor VEGF expression in non-small cell lung cancer(NSCLC) patients, and to evaluate the value of D-dimer in predicting survival time.</p><p><b>METHODS</b>A retrospective review of the clinicopathological data of 290 NSCLC patients confirmed pathologically in Tianjin Cancer Hospital from July 2007 to April 2009 was performed. The correlations between plasma baseline D-dimer levels and clinicopathological characteristics and progonosis were analyzed.</p><p><b>RESULTS</b>For 290 NSCLC patients with low ( ≤ 0.3 µg/ml) and high (>0.3 µg/ml) D-dimer levels, the median survival times were 54.0 months and 46.2 months, respectively (P < 0.05), and for the patients with stages I, II, IIIA, IIIB and IV NSCLC, the median survival times were 58.1, 40.6, 26.7 and 23.5 months, respectively (P < 0.05). In the operable patients (stages I, II and IIIa) with low and high D-dimer levels, the median progression-free survivals (PFS) were 35.0 and 11.0 months, respectively (P < 0.05). Furthermore, the median PFSs were 57.2 months and 19.6 months, respectively, in these operable patients without and with lymph node metastasis (P < 0.05).</p><p><b>CONCLUSIONS</b>High levels of baseline plasma D-dimer may indicate advanced disease stage, larger tumor size, lymph node metastasis and stronger tumor angiongenesis to some extent, and may be useful in prediction of survival time in NSCLC patients of different stages.</p>


Sujets)
Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Humains , Mâle , Adulte d'âge moyen , Protocoles de polychimiothérapie antinéoplasique , Utilisations thérapeutiques , Carcinome pulmonaire non à petites cellules , Sang , Traitement médicamenteux , Anatomopathologie , Chirurgie générale , Cisplatine , Utilisations thérapeutiques , Survie sans rechute , Produits de dégradation de la fibrine et du fibrinogène , Métabolisme , Études de suivi , Tumeurs du poumon , Sang , Traitement médicamenteux , Anatomopathologie , Chirurgie générale , Métastase lymphatique , Stadification tumorale , Paclitaxel , Pneumonectomie , Méthodes , Modèles des risques proportionnels , Études rétrospectives , Taux de survie , Taxoïdes , Utilisations thérapeutiques , Charge tumorale , Facteur de croissance endothéliale vasculaire de type A , Métabolisme
2.
Chinese Journal of Plastic Surgery ; (6): 101-104, 2012.
Article Dans Chinois | WPRIM | ID: wpr-246887

Résumé

<p><b>OBJECTIVE</b>To offer both the accurate three-dimensional anatomical information and algorithmic morphology of perforators in the lower leg for perforator flaps design.</p><p><b>METHODS</b>The cadaver was injected with a modified lead oxide-gelatin mixture. Radiography was first performed and the images were analyzed using the software Photoshop and Scion Image. Then spiral CT scan was also performed and 3-dimensional images were reconstructed with MIMICS 10.01 software.</p><p><b>RESULTS</b>There are (27 +/- 4) perforators whose outer diameter > or = 0.5 mm ( average, 0.8 +/- 0.2 mm). The average pedicle length within the superficial fascia is (37.3 +/- 18.6) mm. The average supplied area of each perforator is (49.5 +/- 25.5) cm2. The three-dimensional model displayed accurate morphology structure and three-dimensional distribution of the perforator-to- perforator and perforator-to-source artery.</p><p><b>CONCLUSIONS</b>The 3D reconstruction model can clearly show the geometric, local details and three-dimensional distribution. It is a considerable method for the study of morphological characteristics of the individual perforators in human calf and preoperative planning of the perforator flap.</p>


Sujets)
Humains , Artères , Cadavre , Traitement d'image par ordinateur , Méthodes , Imagerie tridimensionnelle , Jambe , Lambeau perforant , Lambeaux chirurgicaux
3.
Chinese Journal of Hematology ; (12): 733-737, 2012.
Article Dans Chinois | WPRIM | ID: wpr-278323

Résumé

<p><b>OBJECTIVE</b>To investigate the expressions of GRα, GRβ, GRγ, GRp and heat shock protein 90 (HSP90) in primary immune thrombocytopenia (ITP) patients and their correlations with glucocorticoid resistance.</p><p><b>METHODS</b>The expressions of glucocorticoid receptors (GRα, GRβ, GRγ, GRp) mRNA and HSP90 in peripheral blood mononuclear cells of 40 newly diagnosed ITP patients and 29 healthy volunteers were examined by real time PCR. Of them, 28 patients received glucocorticoid (GC) therapy divided into GC sensitive group (GCS) and GC resistant group (GCR) according to GC response. GRα, GRβ, GRγ, GRp, HSP90 mRNA and HSP90/GRα were analyzed in paired groups.</p><p><b>RESULTS</b>The expression of HSP90 mRNA was significantly decreased in ITP patients \[0.91(0.48 - 2.21)\] than in normal subjects \[1.41(0.83 - 2.61)\] (P < 0.05). There were no significant differences in mRNA expressions of GRα, GRβ, GRγ, GRp and HSP90/GRα between ITP patients and normal controls. The expression of GRα mRNA in GCS patients was significant higher than in GCR patients (P < 0.05). Moreover, no significant differences in mRNA expressions of GRβ, GRγ, GRp and HSP90 and the ratio of HSP90 to GRα were observed between GCS and GCR patients.</p><p><b>CONCLUSION</b>The expression of HSP90 mRNA decreased in adult ITP patients. GC resistance in adult ITP patients was associated with reduced expression of GRα. The very low expression of GRβ mRNA may be not involved in GC resistance in adult ITP.</p>


Sujets)
Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Études cas-témoins , Glucocorticoïdes , Métabolisme , Protéines du choc thermique HSP90 , Génétique , Métabolisme , ARN messager , Génétique , Récepteurs aux glucocorticoïdes , Métabolisme , Thrombopénie , Métabolisme
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