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China Journal of Chinese Materia Medica ; (24): 896-899, 2010.
Article Dans Chinois | WPRIM | ID: wpr-281691

Résumé

<p><b>OBJECTIVE</b>To study the effect and its mechanism of antihypertensive of drug combination of Jimaitong tablt and nifedipine on spontaneously hypertensive rats.</p><p><b>METHOD</b>The spontaneously hypertensive rats (SHR) were treated by intragastric administration (ig) with Jimaitong (450 mg x kg(-1)), Jimaitong (300 mg x kg(-1)) combined with the nifedipine (0.5 mg x kg(-1)), nifedipine (5 mg x kg(-1)) for 8 weeks. Blood pressure and heart rate was measured. The level of oxidation indicators, lipid indicators, as well as hormones related to blood pressure was detected.</p><p><b>RESULTS</b>Compared with that in the control group, systolic blood pressure, diastolic blood pressure, mean arterial pressure of SHR decreased significantly in all the three administration groups (P < 0.01). Heart rates of nifedipine group was faster than other groups (P < 0.05). In combination group, contents of URE, MDA, ET and Ang II were decreased significantly (P < 0.05, P < 0.05, P < 0.05, P < 0.01), the contents of NO and CAMP, SOD and NOS were significantly enhanced (P < 0.05).</p><p><b>CONCLUSION</b>Combination use of Jimaitong and nifedipine has synergistic effects on anti-hypertension in spontaneously hypertensive rats. It indicates the potential applications of combination of traditional Chinese medicine and western medicine for the hypertension treatment.</p>


Sujets)
Animaux , Femelle , Mâle , Rats , Angiotensine-II , Sang , Métabolisme , Antihypertenseurs , Pharmacologie , Utilisations thérapeutiques , Pression sanguine , Association médicamenteuse , Rythme cardiaque , Hypertension artérielle , Sang , Traitement médicamenteux , Malonaldéhyde , Sang , Nifédipine , Pharmacologie , Utilisations thérapeutiques , Nitric oxide synthase , Sang , Rats de lignée SHR , Superoxide dismutase , Sang , Comprimés
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