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Abstract@#As a new type of pollutant, microplastics have attracted extensive attention. Children in a critical stage of growth and development are vulnerable to microplastics. Summarzing the relevant laws and regulations and the source of microplastics, the paper demonstrates the ways of microplastics entering human body, some toxic effects of microplastics found in recent experimental studies and their potential hazards to children s health are introduced in detail.
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Objective To explore protective effects of ulinastatin on lung injury and inflammation in patients received pulmonary surgeries.Methods 36 patients received pulmonary surgeries were randomly divided into control group and experimental group,and OLV was applied during surgeries.Additionally,ulinastatin was given to experimental group.Serum levels of IL-6,IL-10 and TNF-alpha were observed at different time after OLV by ELSIA.The expression of AQP-4 was observed by immunohistochemistry.Results Serum levels of IL-6,IL-10 and TNF-alpha increased significantly in all patients after OLV was applied(P ＜0.05).The levels of IL-6 and TNF-alpha increased more significantly in experimental group than control group at all time points.The expression of AQP-4 increased significantly in experimental group than control group(t =10.29,P ＜ 0.05).Conclusion Conclusion Ulinastatin shows protective effects on lung injury during pulmonary surgeries,mainly via attenuating inflammation reactions and expression of AQP-4.
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AIM:To investigate the effect of intravenous infusion of lidocaine on postoperative pain,return of bowel function and stress response after hysterectomia surgery. METHODS:Sixty patients scheduled to undergo hysterectomia surgery were randomly divided into two groups with thirty in each group. Group L received intravenous lidocaine bolus injection of 1.5 mg/kg at induction of anesthesia,then continuous infusion of 1 mg?kg-1?h-1 intraoperatively and infusion of 100 mg plus sulfentanyl 50 mg for 48 h postperatively. Group S received an equal volume saline and infusion of sulfentanyl 100 mg for 48 h postperatively. Postoperative pain score at rest and cough were recorded by VAS. The times of first flatus,enterocinesia were recorded and the levels of motilin,cortisol and serum glucose were measured. RESULTS:Lidocaine significantly reduced postoperative pain,nause and vomit scores. Times to first flatus,enterocinesia were significantly shorter in patients who received lidocaine. the levels of motilin were significantly higher,but the levels of cortisol and serum glucose were significantly lower in Group L than in Group S. CONCLUSION:Intravenous lidocaine relieves postoperative pain,improve bowel function through increasing plasma motilin levels and decreasing stress responses after hysterectomia surgery.