Application of mapping allele with resolved carrier status technique for preimplantation genetic testing in carriers with balanced chromosomal translocations / 中华医学遗传学杂志

OBJECTIVE@#To assess the application value of mapping allele with resolved carrier status (MaReCs) technique for preimplantation genetic testing (PGT).@*METHODS@#The characteristics of MaReCs for PGT and outcome of patients were retrospectively analyzed.@*RESULTS@#Compared with those who could not use the technique, carriers who have used the MaReCs technique were younger, had significantly higher level of anti-Mullerian hormone, more antral follicles, occytes, mature occytes, biopsied embryos and euploid embryos, and lower risks for de novo chromosomal abnormality (P 0.05). Carriers undergoing MaReCs test could preferentially select embryos with normal chromosome structures for the transfer.@*CONCLUSION@#Application of MaReCs has a prerequisite for having a minimum number of occytes and biopsied embryos and using discarded embryos sometimes. MaReCs is efficient for the detection of carrier status of embryos and attaining higher rate of pregnancy and live birth, which can significantly improve the outcome for couples carrying chromosomal translocations.

Determination of succinic acid in Rhizoma Pinelliae in various areas by TCL-scanning / 中成药

Objective: To compare Succinic Acid of Rhizoma Pinelliae in viarious areas in China.Method: Using the technology of TCL.Result:Succinic Acid in various areas in China are not very close to one another.The highest amount is in Shanxi Province(about 0.0254% )and the lowest amount is in Hunan Province(about 0.0038% ).Conclusion:There are obvious differences of Succinic Acid among various areas in China.Succinic Acid shoule be between 0.0038%～0.0254%