Mechanism of heroin promoting addiction and relapse in progeny of male rats by inhibiting promoter methylation of imprinted gene H19 by down-regulating DNMT3a / 中国药理学通报

Aim To investigate the effect of heroin use in male rats of F0 generation on heroin addiction and relapse in rats of Fl generation and the underlying mechanism. Methods Male rats of F0 generation were treated with different doses of heroin (1, 3, 9 mg • kg

Promoting effect of father presence on the mental health diathesis of junior middle school students / 中国学校卫生

Objective@#To study the relationship between the father presence and the mental health diathesis of the middle school students,and to provide a reference for targetedly instructing fathers’ participation into family education.@*Methods@#The participants were selected by using random whole class sampling method and Father Presence Questionnaires (FPQ-R-B), and then 577 junior middle school students were recruited, including high and low level of father presence(HF & LF). Chinese Adolescent Mental Health Diathesis was used to investigate the effect of father presence on eight subscales of mental health diathesis.@*Results@#Single factor ANOVA showed that in the subscales of coping style (2.84±0.52,2.80±0.60), self (2.87±0.56,2.79±0.59), attribution style (2.85±0.56,2.78±0.55) and adaptation (2.92±0.56,2.85±0.59), HF group scored significantly higher than LF group(F=4.32,5.27,7.13,8.62,P<0.05). Simple effect analysis reveals that for girls there was no significant difference between the HF and LF groups (2.87±0.45,2.86±0.48, P>0.05), but for boys the score of the HF group was significantly higher than that of the LF group(2.93±0.34,2.85±0.40)(F=5.93,P<0.05).@*Conclusion@#High level of father presence is related to better performance in coping style, self, attribution style, adaptation, and personality quality, and its impact on personality qualitty shows gender differences.