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2.
Article Dans Anglais | IMSEAR | ID: sea-119747

Résumé

Acute fatty liver of pregnancy is an uncommon, potentially fatal disorder. Between 1998 and 2000, two patients with acute fatty liver of pregnancy presented at the Christian Medical College Hospital, Vellore. Both patients were in the thirty-sixth week of pregnancy. jaundice and encephalopathy were the predominant symptoms. Both the mothers died after they delivered a stillborn Infant each. The maternal deaths were due to multiorgan failure and/or postpartum haemorrhage and sepsis. The route of delivery was vaginal in both the patients. Extrahepatic and metabolic complications in both cases Included renal failure, sepsis, hypoglycaemia, disseminated intravascular coagulation and gastrointestinal bleeding. Liver biopsy done in both patients was consistent with the diagnosis of acute fatty liver of pregnancy. To the best of our knowledge, this is the first report from India on acute fatty liver of pregnancy.


Sujets)
Maladie aigüe , Adolescent , Adulte , Diagnostic différentiel , Issue fatale , Stéatose hépatique/diagnostic , Femelle , Humains , Grossesse , Complications de la grossesse/diagnostic
3.
Indian J Pathol Microbiol ; 2002 Jul; 45(3): 329-31
Article Dans Anglais | IMSEAR | ID: sea-75446

Résumé

Epithelioid haemangioendothelioma is a well-recognized vascular neoplasm but can be mistaken for metastatic adenocarcinoma or other primary liver tumors. We present a case of epithelioid haemangioendothelioma of the liver in a 62 year old woman, in whom the diagnosis was missed by various pathologists. This patient presented with loss of appetite and weight, and fever. She rapidly deteriorated and died presumably of liver cell failure. The characteristic histological features and the positive immunostaining for endothelial markers (CD31 & Ulex europaeus) confirmed the diagnosis.


Sujets)
Femelle , Hémangioendothéliome épithélioïde/composition chimique , Humains , Tumeurs du foie/anatomopathologie , Adulte d'âge moyen , Tumeurs vasculaires/anatomopathologie
4.
Article Dans Anglais | IMSEAR | ID: sea-119444

Résumé

BACKGROUND: Wilson's disease usually presents in childhood. Early recognition and treatment is crucial to retard the progression of this disease, which can be debilitating, if not fatal. We analysed the clinical manifestations and survival pattern of patients admitted at our centre from 1993 to 1996. METHODS: Hospital records of patients were reviewed to obtain the clinical manifestations. The survival status of patients was determined by a prospective follow up. The Kaplan-Meier survival curve and univariate Cox proportional hazards model were used to determine the survival pattern and risk for death in Wilson's disease. RESULTS: A total of 60 patients were studied. The median age at onset of symptoms was 12 years (range 5-52 years). The log rank test showed a significant difference in the mean (SD) survival between patients who presented with hepatic [87.36 (15.26) months] and neurological symptoms [114.33 (9.14) months]. Cox proportional hazards analysis showed a hazard ratio of 4.9 for patients with a hepatic presentation compared to those with neurological presentation. CONCLUSION: The presentation of Wilson's disease is not limited to the paediatric age group. Patients with a hepatic presentation had a five-fold higher risk of mortality when compared to those with a neurological presentation.


Sujets)
Adolescent , Adulte , Âge de début , Analyse de variance , Enfant , Enfant d'âge préscolaire , Femelle , Dégénérescence hépatolenticulaire/traitement médicamenteux , Humains , Inde/épidémiologie , Mâle , Adulte d'âge moyen , Modèles des risques proportionnels , Études rétrospectives , Taux de survie
5.
Article Dans Anglais | IMSEAR | ID: sea-64675

Résumé

Vesical varices in portal hypertension are rare. We report a patient with portal hypertension who developed recurrent painless hematuria. Cystoscopy was normal. Doppler ultrasound and MR angiography showed a dilated paraumbilical vein within the falciform ligament coursing down to the urinary bladder wall and draining into the right internal iliac vein. He underwent liver transplantation for decompensated chronic liver disease. He is in good health and has not had further episodes of hematuria.


Sujets)
Adulte , Cystoscopie , Études de suivi , Humains , Hypertension portale/complications , Cirrhose du foie/complications , Transplantation hépatique , Mâle , Vessie urinaire/vascularisation , Varices/complications
6.
Indian Pediatr ; 1990 Feb; 27(2): 134-42
Article Dans Anglais | IMSEAR | ID: sea-9457

Résumé

The acetylator phenotype of 180 children aged 3-11 years was determined on the basis of isoniazid concentrations in saliva collected at 5 hours after oral administration of body-weight and surface-area-related dosages of the drug in a syrup form. Isoniazid 2.5 mg/kg was administered on one occasion and 75 mg/m2 surface-area on another, with an interval of 3 days between the occasions. A cross-over design was employed and the sequence was determined by random allocation. The distribution of the concentrations was bimodal with both procedures, indicating the presence of two groups namely, the slow and rapid acetylators. The criterion for a rapid acetylator was a concentration of 0.3 micrograms/ml or less by body-weight-related dosage and 0.4 micrograms/ml or less by that based on surface-area. Based on these criteria, 62% of the children were classified as slow acetylators and 38% as rapid acetylators by body-weight, and 59 and 41%, respectively by surface-area, and the findings were similar in children in the different age-groups. The agreement between the two procedures was 98%.


Sujets)
Acétylation , Acetyltransferases/génétique , Administration par voie orale , Surface corporelle , Poids , Enfant , Enfant d'âge préscolaire , Relation dose-effet des médicaments , Humains , Isoniazide/administration et posologie , Phénotype , Salive/analyse
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