fibrinolytic activity of intact and lysed leukocytes in different types of acute leukemia

The fibrinolytic activity of leukocytes from 56 patients with different types of acute leukemia and 20 normal subjects constituting the control group, was assayed by the fibrin plate method. There was no significant difference in the fibrinolytic activity between intact and lysed leukocytes in the control group, the whole acute myelogenous group, the fibrmolytic activity of intact cells was significantly higher than that of lysed cells. A significant correlation was found to exist between the fibrinolytic activity of intact and lysed cells in each of the control and leukemia groups except M3 and M4 subgroups. In the meantime, a significant increase in fibrinolytic activity of leukocytes was demonstrated in all leukemic groups compared to that of the control, except M4 subgroup and acute lymphoblastic leukemia group, in which this increase was not significant. Fibrinolytic activity of normal and leukemic leukocytes was found to be independent of plasminogen

Coagulation disorders in different types of acute leukemia

The results of the coagulation studies performed on blood from 32 leukemic patients with different types of acute leukemia showed evidence in favor of fibrinolysis. The fibrinolysis seems to occur as a primary process independent of DIC, as a result of the release of enzymes with fibriolytic activity from the leukemic leukocytes