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1.
Braz. j. med. biol. res ; 34(8): 1079-1084, Aug. 2001. ilus
Article Dans Anglais | LILACS | ID: lil-290157

Résumé

For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption


Sujets)
Animaux , Angiotensine-II/physiologie , Angiotensine-I/physiologie , Espace extracellulaire/enzymologie , Tubules contournés proximaux/enzymologie , Sodium-Potassium-Exchanging ATPase/métabolisme , Sodium/urine , Espace extracellulaire/physiologie , Récepteurs aux angiotensines/physiologie
2.
Braz. j. med. biol. res ; 34(3): 315-323, Mar. 2001. ilus, tab
Article Dans Anglais | LILACS | ID: lil-281611

Résumé

Nephrolithiasis is one of the most common diseases in the Western world. The disease manifests itself with intensive pain, sporadic infections, and, sometimes, renal failure. The symptoms are due to the appearance of urinary stones (calculi) which are formed mainly by calcium salts. These calcium salts precipitate in the renal papillae and/or within the collecting ducts. Inherited forms of nephrolithiasis related to chromosome X (X-linked hypercalciuric nephrolithiasis or XLN) have been recently described. Hypercalciuria, nephrocalcinosis, and male predominance are the major characteristics of these diseases. The gene responsible for the XLN forms of kidney stones was cloned and characterized as a chloride channel called ClC-5. The ClC-5 chloride channel belongs to a superfamily of voltage-gated chloride channels, whose physiological roles are not completely understood. The objective of the present review is to identify recent advances in the molecular pathology of nephrolithiasis, with emphasis on XLN. We also try to establish a link between a chloride channel like ClC-5, hypercalciuria, failure in urine acidification and protein endocytosis, which could explain the symptoms exhibited by XLN patients


Sujets)
Humains , Mâle , Femelle , Animaux , Canaux chlorure/physiologie , Calculs rénaux/génétique , Rein/métabolisme , Néphrocalcinose/génétique , Calcium/urine , Endocytose , Liaison génétique , Rein/physiopathologie , Minéraux/métabolisme , Mutation , Facteurs sexuels , Syndrome , Chromosome X
3.
Braz. j. med. biol. res ; 32(8): 1021-8, Aug. 1999.
Article Dans Anglais | LILACS | ID: lil-238972

Résumé

Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). Mutations in the CFTR gene may result in a defective processing of its protein and alter the function and regulation of this channel. Mutations are associated with different symptoms, including pancreatic insufficiency, bile duct obstruction, infertility in males, high sweat Cl-, intestinal obstruction, nasal polyp formation, chronic sinusitis, mucus dehydration, and chronic Pseudomonas aeruginosa and Staphylococcus aureus lung infection, responsible for 90 percent of the mortality of CF patients. The gene responsible for the cellular defect in CF was cloned in 1989 and its protein product CFTR is activated by an increase of intracellular cAMP. The CFTR contains two membrane domains, each with six transmembrane domain segments, two nucleotide-binding domains (NBDs), and a cytoplasmic domain. In this review we discuss the studies that have correlated the role of each CFTR domain in the protein function as a chloride channel and as a regulator of the outwardly rectifying Cl- channels (ORCCs)


Sujets)
Humains , Canaux chlorure/physiologie , Protéine CFTR/composition chimique , Protéine CFTR/physiologie , Mucoviscidose/génétique , Protéine CFTR/génétique
4.
Braz. j. med. biol. res ; 23(8): 739-42, 1990. ilus
Article Dans Anglais | LILACS | ID: lil-92333

Résumé

Thin ascending limb cells from Henle's loop were optical and video techniques to evaluate cell volume regulation in response to anisoosmotic media and its ionic dependence. Cell volume regulation was observed when these cells were exposed to, hypoosmotic solutions. Under hyperosmotic conditions only an osmometric reponse was found, with no volume regulatory increase (VRI). The removal of Cl- or HCO3- abolished the volume regulatory decrease (VRD) normally observed during exposure to hypoosmotic soloutions. Re-addition of these ions did not elicit the VRD response. The removal of K+ from hypoosmotic solutions abolished VRD but is re-introduction restored the volume regulatory reponse. In the absence of Na+, a partial inhibition of VRD was found; re-addition of Na+ completely restored the regulatory response. These indicate that cells from the thin ascending limb of Henle's loop regulate their volume under hypoosmotic conditions, and that this process is dependent upon Cl-, HCO3-, Na+ and K+, with different patterns of response being observed upon addition or deltion of these ions


Sujets)
Rats , Animaux , Femelle , Anse de Henlé/métabolisme , Anse de Henlé/cytologie , Cellules cultivées/physiologie , Concentration osmolaire , Rat Wistar , Équilibre hydroélectrolytique
5.
J. bras. nefrol ; 7(1): 13-6, mar. 1985. tab
Article Dans Portugais | LILACS | ID: lil-2082

Résumé

O efeito do ácido tienílico sobre a excreçäo de água e sal, bem como sobre o processo de acidificaçäo urinária, foi estudado em ratos-controle e em animais submetidos a acidose metabólica aguda por infusäo de cloreto de amônio. Os resultados obtidos levam às seguintes conclusöes: 1) a cepa de ratos por nós utilizada é sensível aos efeitos saluréticos do ácido tienílico, sendo um possível modelo para seu estudo; 2) o efeito máximo da droga utilizada via intraperitoneal na concentraçäo de 50mg/kg de peso corpóreo se dá entre 30 e 60 minutos após sua administraçäo; 3) a droga também modifica a excreçäo renal de ácidos, provocando drástica queda do pH urinário e aumento da excreçäo de acidez titulável; 4) na vigência de acidose metabólica a droga näo tem açäo diurética, apesar de aumentar a acidificaçäo urinária


Sujets)
Rats , Animaux , Mâle , Acides/urine , Acidose/induit chimiquement , Concentration en ions d'hydrogène , Acide tiénilique/pharmacologie , Chlorure d'ammonium/pharmacologie
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