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1.
Korean Journal of Urology ; : 310-317, 2015.
Article Dans Anglais | WPRIM | ID: wpr-34596

Résumé

PURPOSE: To investigate the potential benefits of testosterone administration to elderly men (>65 years) with late-onset hypogonadism (LOH) in comparison with younger men and to assess the safety of testosterone administration to elderly men. MATERIALS AND METHODS: A total of 561 hypogonadal men from two registry studies were divided into age groups of 65 years (group O, n=111; range, 66-84 years). Following an initial 6-week interval, all men were treated with 3-month injections of parenteral testosterone undecanoate for up to 6 years. RESULTS: Over the 6 years, there was a progressive decrease of body weight and waist circumference. Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first 24 to 42 months and were sustained. Rather than a deterioration, there was an improvement of urinary parameters. Prostate volume and prostate-specific antigen increased moderately. Hematocrit levels increased but remained within safe margins. CONCLUSIONS: The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins. Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.


Sujets)
Sujet âgé , Humains , Mâle , Adulte d'âge moyen , Facteurs âges , Âge de début , Androgènes/administration et posologie , Anthropométrie/méthodes , Surveillance des médicaments/méthodes , Allemagne , Hypogonadisme/diagnostic , Taille d'organe , Prostate/effets des médicaments et des substances chimiques , Antigène spécifique de la prostate/analyse , Enregistrements , Comportement sexuel/effets des médicaments et des substances chimiques , Testostérone/administration et posologie , Résultat thérapeutique
2.
Asian Journal of Andrology ; (6): 291-297, 2007.
Article Dans Anglais | WPRIM | ID: wpr-310511

Résumé

Testosterone (T) as a compound for treatment of T deficiency has been available for almost 70 years, but the pharmaceutical formulations have been less than ideal. Traditionally, injectable T esters have been used for treatment, but they generate supranormal T levels shortly after the 2-3 weekly injection interval. T levels then decline very rapidly, becoming subnormal during the days preceding the next injection. The rapid fluctuations in plasma T are subjectively experienced as disagreeable. T undecanoate (TU) is a new injectable T preparation with a considerably better pharmacokinetic profile. After two initial injections separated by a 6-week interval, the following intervals between two injections are generally 12 weeks, eventually amounting to a total of four injections per year. Plasma T levels with this preparation are nearly always in the range of normal men, as are its metabolic products estradiol and dihydrotestosterone (DHT). It reverses the effects of hypogonadism on bone and muscle and metabolic parameters, and on sex functions. It is suitable for male contraception. Its safety profile is excellent because of the continuous normalcy of plasma T levels. No polycythemia has been observed and no adverse effects on lipid profiles. Prostate safety parameters are well within reference limits. TU is a valuable treatment option of androgen deficiency.


Sujets)
Humains , Mâle , Contraceptifs masculins , Pharmacocinétique , Utilisations thérapeutiques , Dysfonctionnement érectile , Traitement médicamenteux , Hypogonadisme , Traitement médicamenteux , Injections musculaires , Testostérone , Sang , Pharmacocinétique , Utilisations thérapeutiques , Congénères de la testostérone , Pharmacocinétique , Utilisations thérapeutiques
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