Résumé
Objective: To find out the preventive effect of flaxseed oil on the hepatic damage produced by the Lipofundin, a soya-bean based lipid emulsion used in parenteral therapies
Study Design: Experimental study
Place and Duration of Study: The study was carried out at the University of Health Sciences, Lahore for a period of one year, from Jan 2015 to Dec 2015
Material and Methods: Experimental study has been performed to study the effect of flaxseed oil on the lipofundin induced hepatotoxicity. Thirty-two male adult albino rats were obtained from animal house of University of Health Sciences, Lahore and divided into four equal groups. Group A [control group] was given flaxseed oil 3ml/kg intraperitonially daily for 10 days and sacrificed on day 11. Group B was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 11. Group C was given Lipofundin 2ml/kg intravenously daily for 10 days and sacrificed on day 21. Group D was given Lipofundin 2ml/kg intravenously for 10 days followed by Flaxseed oil 3ml/kg intraperitonially for 10 days and sacrificed on day 21
Results: Flaxseed oil was observed to restore the hepatic tissue damage caused by the lipofundin administration
Conclusion: Flaxseed oil has an ameliorative effect on the hepatic tissue damage caused by the Lipofundin.Hence its use may help prevent hepatic tissue damage caused by lipofundin used in parenteral therapies
Résumé
Objective: To see the effects of Nigella sativa on acetylsalicylic acid-induced nephrotoxicity in albino rats
Study Design: An experimental study
Place and Duration of Study: The Anatomy Department of University of Health Sciences, Lahore, from January 2014 to December 2015
Methodology: Thirty-two female albino rats were divided into four groups. Group A [control] was given single dose of 10 mg/100 gm body weight of 1% methylcellulose, orally. Group B and C were treated with oral 1000 mg/kg acetylsalicylic acid as a single dose. Group D was given 250 mg/kg ethanolic extract of Nigella sativa [NSE] by oral gavage followed by single dose of 1000 mg/kg acetylsalicylic acid on 1st day of experiment; after that only NSE was continued till 7 days. Animals of groups A, C and D were sacrificed on day 8 and that of group B on day 2 of experiment. Cardiac puncture was performed to draw blood from each animal for renal function tests. Animals were evaluated for gross [Paired kidney weight, body weight, relative tissue body weight index] as well as for biochemical [Serum urea and creatinine] parameters
Results: Gross as well as biochemical parameters were markedly impaired in group B, but statistically significant improvement was noticed in Nigella sativa treated group. There was no self recovery in group C
Conclusion: Ethanolic extract of Nigella sativa has a protective role against acetylsalicylic acid-induced nephrotoxicity in albino rats