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Int. braz. j. urol ; 43(2): 335-344, Mar.-Apr. 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-840821

Résumé

ABSTRACT Objective To validate the application of the bacterial cellulose (BC) membrane as a protecting barrier to the urethra. Materials and Methods Forty female Wistar rats (four groups of 10): Group 1 (sham), the urethra was dissected as in previous groups and nothing applied around; Group 2, received a 0.7cm strip of the BC applied around the urethra just below the bladder neck; Group 3, received a silicon strip with the same dimensions as in group 2; Group 4, had a combination of 2 and 3 groups being the silicon strip applied over the cellulosic material. Half of the animals in each group were killed at 4 and 8 months. Bladder and urethra were fixed in formalin for histological analysis. Results Inflammatory infiltrates were more intense at 4 months at lymphonodes (80% Grade 2), statistically different in the group 2 compared with groups 1 (p=0.0044) and 3 (p=0.0154). At 8 months, all samples were classified as grade 1 indicating a less intense inflammatory reaction in all groups. In group 2, at 8 months, there was a reduction in epithelial thickness (30±1μm) when com-pared to groups 1 (p=0.0001) and 3 (p<0.0001). Angiogenesis was present in groups 2 and 4 and absent in group 3. In BC implant, at 4 and 8 months, it was significant when comparing groups 4 with 1 (p=0.0159). Conclusion BC membrane was well integrated to the urethral wall promoting tissue remodeling and strengthening based on morphometric and histological results and may be a future option to prevent urethral damage.


Sujets)
Animaux , Femelle , Bactéries , Urètre/traumatismes , Maladies de l'urètre/prévention et contrôle , Matériaux biocompatibles/pharmacologie , Cellulose/pharmacologie , Sphincter urinaire artificiel/effets indésirables , Implantation de prothèse/effets indésirables , Silicone/pharmacologie , Facteurs temps , Urètre/anatomopathologie , Maladies de l'urètre/anatomopathologie , Incontinence urinaire/chirurgie , Reproductibilité des résultats , Résultat thérapeutique , Rat Wistar , Modèles animaux , Membranes
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