Chromium interaction with iron metabolism in rat: a model study in relation to hemodialysis patients

The interaction between chromium and some serum iron related parameters were investigated. Intraperitoneal administration of 1 mg/kg chromium [as chromium chloride] for 45 days reduced the serum iron and total iron binding capacity by 27% and 11% respectively. Ferritin and hemoglobin concentrations were also reduced by 22% and 18%, respectively. The results suggest that chromium influences iron metabolism and these two elements are biochemically interrelated