[ effect of acetone extract of Moringa peregrina on Trichomonas vaginalis, Candida albicans and macrophage cells in vitro]

Background and Aim: Vulvovaginal candidiasis and trichomoniasis account for at least 50 percent of all cases of vaginal infections. The main drugs used to treat these infections have numerous side effects and drug resistance to them is on the rise. The aim of this study was to investigate the anti-trichomonas and anti candidal effects of acetone extracts of Moringa peregrina in vitro

Material and Methods: We used acetone extracts of Moringa peregrina at concentrations of 375, 750, …, 3000 and 4000 microg/ml for the treatment of trichomoniasis; and concentrations of 0/003,…, 1 and 2mg/ml for the treatment of candidiasis. We evaluated the effect of the extracts after 24 and 48 hours. The final number of viable parasites were determined by trypan blue staining and neobar lamella; and IC50 [50% Inhibitory Concentration] value was calculated. We also calculated MIC [Minimum Inhibitory Concentration] of the extract for candida. The cytotoxic effect of the extract on the mice macrophage cells was investigated

Result: Comparison between treatment and control groups revealed a significant decrease in the viability of parasites in the treatment group at all concentrations after both 24 and 48 hours [P<0.05]. After 24 hours the IC50 and SI values were calculated as 682 and 4.1 for parasite respectively and MIC value was 2 mg/ml for Candida albicans

Conclusion: Considering favorable effects of acetone extract of Moringa peregrina on inhibiting the growth of Trichomonas vaginalis and Candida albicans identification and isolation of active ingredients of the plant, may lead to use of this extract for the treatment of both infections in the future studies

Changes in antibiotic use in a general surgery unit over a 5-year period

Concerns have been expressed about the overuse of antibiotics in inpatient settings. We compared the pattern of antibiotic use in 2010 in a surgical unit of a university hospital in the Islamic Republic of Iran with similar data from 2006. Defined daily doses per 100 bed-days [DBD] were calculated. Overall use of antibiotics in our surgical unit increased significantly from a mean of 4.9 [SD 5.1] DBD in 2006 to 7.7 [SD 10.3] DBD in 2010. This increase was mainly due to increases in the use of antibiotics for treatment of infections; the prophylactic use of antibiotics did not show a significant increase. There was an increase in the consumption of ceftriaxone, imipenem, cefalotin, metronidazole and vancomycin, a decrease in the use of erythromycin and ceftazidime and no change in the use of ciprofloxacin and clindamycin. Ceftriaxone showed the greatest increase [5.1-fold] and erythromycin the sharpest decrease [8-fold] in use

[Status of self- care ability of patients with Rheumatoid Arthritis]

Introduction: today medical world is facing the increase of chronic diseases. Rheumatoid Arthritis as a chronic disease causes pain, fatigue, limited mobility and daily activity, physical function disorder and disability. An important part of controlling chronic illnesses such as rheumatoid arthritis is enabling patients to conduct self-care and adjusting to condition of chronic disease

Objective: present study aims to determine self-care ability of patients with rheumatoid arthritis

Methods: this is a cross sectional descriptive study which surveyed the level of self-care of 326 patients with rheumatoid arthritis referring to Rheumatology clinic of Razi educational center in Rasht. Data were collected using Health Assessment Questionnaire in order to determine the disability rate and Self-Care Inventory in order to determine the Self-Care ability rate through interview. Data were analyzed by descriptive and analytical statistical tests [Kruskal Wallis, Mann Whitney and Multiple linear regressions]

Results: the mean self-care ability of patients was 57.65+/-2.32 which was at a good level. Sex [P<0.0016]], age [P<0.001] marital status [P<0.001], education [P<0.001], jobs [P<0.001], income [P<0.004], duration of illness [P<0.000] and co morbidities [P<0.001] were significantly associated with self-care ability

Conclusion: study findings indicate that baseline factors are effective in controlling rheumatoid arthritis disease; therefore it is necessary for nurses to determine self-care needs considering effective related factors to develop and implement training programs in order to improve patients' empowerment

[Effect of hydroalcoholic extract of chevil [ferulago angulata] on glucose and lipid in diabetic male rats]

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats

Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups [n=9 each] and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by oneway ANOVA

Results: Findings showed a significant reduction [P<0.05] of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively], Triglycerides [at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%], Cholesterol [800 mg/kg of the extract, 20.9%], LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase [P<0.05] in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil

Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats

[In Vitro Evuluation of Flow and Working Time of AH PIus Alone and in Combinution with Amoxicillin und Triple Antibiotic Paste]

Background and Aim: Some researchers have attempted to enhance the antibacterial properties of sealers byaddition of antibiotics while this may affect their physical properties.The purpose of this in vitro study was to comparethe working time and flow of AH Plus sealer alone and in combination with amoxicillin and triple antibiotic paste [TAP]

Materials and Methods: This in vitro study assessed the flow and working time of AH Plus alone [control group] and in combination with amoxicillin and TAP in 1%, 5%, 10% and 25%concentrationsaccording to ANSI/ADA specification NO. 57. The data were analyzed by ANOVA and Tukey's test.

Results: Statistically significant differences were noted in the flow and working time of control group with those of different concentrations of TAp in combination with sealer [p<0.0001].]. The working time decreased by an increase inthe concentration of TAp. The AH Plus/ 1% TAP and AH Plus/5% TAP showed higher flow than the control group. The AH plus /1% amoxicillin, AH Plus/5% amoxicillinand AH Plus/l0% TAPhad a flow similar to that of the control group. Other groups showed lower flow than the control group.

Conclusion: All the alterations in the physical properties of AH Plus sealer in combination with amoxicillin and TAPwere within the ANSI/ADA specification NO 57 standard range.

[Knowledge and Practice of the students in Tabriz about iron deficiency and iron supplementation]

Iron supplements, is the most cost effective and common strategy used in developed countries for the control of iron deficiency. Weekly iron supplementation programs in high schools and middle schools for girls in 2006, has been carried out. This study aimed to determine the status and practice of female students about iron deficiency and iron supplementation and its relation to personal and social factors. In this cross-sectional study in 2012, 920 pupils from 10 schools were questioned. The questionnaire included demographic information and questions about knowledge and practice. School choice as a quota of five school districts in Tabriz took place. Collected data was analysed by SPSS 13, using inferential statistics methods. The mean [SD] scores of students was 52.4 [13] and practice score was 63.4 [11.3], respectively. 61.6% of the students stated that they "often or always" use tablet distribution. 8% of the sample stated that they had "never" iron distribution in their schools. The most common reason for not taking the tablets was expressed color and taste of the tablets. For better and more effective implementation of iron supplementation programs in schools, iron supplementation and nutrition education classes for students or their mothers and distribution of quality iron tablets are required

Impact of range straggling and multiple scattering on proton therapy of brain, using a slab head phantom

The advantages of proton beam in radiation therapy- like small lateral scattering as well as absence of exit dose tail in the organs which are after the tumor- make it capable of delivering more treatment doses to the target and much lesser to the critical tissues near it. In this study, the Monte Carlo MCNPX code has been used to simulate a slab head phantom irradiated by proton pencil beams. The simplified slab has tissue compositions of the ICRU 46, and the necessary data have been taken from adult male phantom of MIRD-ORNL family series. Suitable energy range of incident proton beams has been estimated in order to have the Bragg peaks inside the brain tissue. Energy straggling or, rather, range straggling, and multiple scattering which affect the lateral broadening of incident beams, have been investigated. The results show that the FWHM [Full Wide in Half Maximum] increases more than six times from 1.73 mm to 10.78 mm for the energy range of 50 - 135 MeV. The FWHM values of lateral dose profiles change from 1 mm in 50 MeV to 7.5 mm in 135 MeV, and it has been shown that when a pencil beam is used to irradiate a tissue, the absorbed dose in depth along the central axis does not show a Bragg peak pattern

[Normative data of semantic fluency in adult Persian speakers]

In some disorders, word finding is difficult. There is different ways to assess naming process that verbal fluency is one way. So far has not been an index to verbal fluency assessment and treatment, the aim of this study was to determine normative data of semantic fluency for 18-69 -year - old adult Persian speakers. This study was cross sectional and analytic. Participants were 540 normal adults 18-69 -year - old. They were divided in 4 age groups [18-30, 31-43, 44-56, 57-69] and 3 educational groups [0-8, 9-12, >12]. The peoples were asked to name animals and fruits in 60 seconds, words were recorded and analyzed whit Troyer method and SPSS 16 software. The findings of this study did not show significant differences in semantic verbal fluency, clusters mean and number of switches between two genders. But significant differences were found in semantic verbal fluency [P=0.000] and number of switching [P=0.000] between educational groups. Also significant differences were found in semantic verbal fluency [P=0.014], clusters [P=0.000] mean and number of switching [P=0.000] between age groups. Semantic verbal fluency and number of switching increase by promoting the education but decrease by rising of participant age. Clusters mean increase by rising of participant but the education had not significant effect. Gender had no effect on none of them. The findings of this study are consistent with other studies and difference in findings in some of studies, could cause of different in educational and age partitions

[Differentiation of embryonal carcinoma stem cells into insulin-producing cells by using pancreas extract in vitro]

Type I diabetes mellitus results from the autoimmune destruction of the p cells in pancreatic islets. Currently, extensive research is being conducted on the generation of insulin-producing cells [IPCs] from stem cells. P19 embryonal carcinoma cells are multipotent and can differentiate into cell types of all three germ layers. In this study, the differentiation of P19 cells into IPCs by using mouse pancreas extract [MPE] was investigated. Embryoid bodies [EBs] obtained from P19 cells were cultured in medium containing 3% fetal bovine serum, supplemented by concentration of 50, 100, 200,300 pg/mL MPE for 7-14 days. Dithizone [DTZ] staining was used to detect IPCs derived from EBs in vitro. Mouse monoclonal insulin-proinsulin and monoclonal insulin receptor beta antibodies were used for immunoflourescence. Insulin content from the cells and insulin secreted by differentiated cells in response to concentrations of 5.5 and 25 mM glucose were measured using ELISA kits. DTZ-positive cells showed purple-red clusters, immunoflourescence indicated expression of Beta cell markers [insulin-proinsulin and insulin receptor beta] in these cells. Increasing glucose concentration, caused more insulin to be secreted by differentiated ceils. P19 cells can in the presence of pancreas extract differentiate to cell producing and secreting insulin cells. Differentiated cells can increase insulin secretion in response to increasing glucose medium

[Effect of moderate-carbohydrate and low-calorie diet on metabolic risk factors, liver enzymes and sonographic findings in patients with non-alcoholic fatty liver disease [NAFLD]]

At present, non-alcoholic fatty liver disease [NAFLD] as the hepatic manifestation of the metabolic syndrome is the most common chronic liver disease. Although there is no cure for it yet, it is considered a priority among approaches for lifestyle modifications. This study was aimed to investigate the effect of moderate-carbohydrate, low-calorie diet in patients with NAFLD. A total of 19 overweight or obese subjects with NAFLD were studied for 6 weeks in a randomized controlled clinical trial. A low-calorie moderate-carbohydrate diet [55% energy from carbohydrate] was designed based on dietary habits, age, gender, height and weight of patients. At beginning and end of the study, biochemical parameters including fasting glucose, liver enzymes, insulin, triglycerides, total cholesterol, high-density lipoprotein [HDL-C] and low-density lipoprotein [LDL-C] cholesterol were assessed and height, weight and blood pressure were measured. Data were analyzed by SPSS software. The average age was 38.94 +/- 8.56 years and body mass index [BMI] was 29.44 +/- 2.88 kg/m2. After six weeks of dietary intervention, weight, fasting glucose levels and enzyme aspartate amino transferase [AST] decreased significantly and HDL cholesterol increased. Hepatic ultrasound findings also showed a relative improvement in 6 patients, and one patient who had a complete remission, statistical significance borderline [p=0.055]. The findings of the present study suggest the role of carbohydrate in low-calorie diets, which significantly improved metabolic status of the liver in NAFLD patients, in more than one third of the subjects over a period of 6 weeks

Use of N-trimethyl chitosan for intranasal delivery of DNA encoding M2e-HSP70c in mice

Influenza outbreak has become a great lifethreatening disease in the world. Nasal vaccines can induce systemic IgG and mucosal IgA antibody responses, which establish two layers of immune defense against the infectious pathogens like influenza. Mucosal vaccines must overcome several limitations, including the mucociliary clearance and inefficient uptake of soluble antigens. Therefore, nasal vaccines require potent adjuvants and delivery systems. In this study we evaluated the effect of N-trimethyl chitosan [TMC] as a potent vehicle for DNA encoding M2e/HSP70c in order for intranasal administration in mice. Ectodomain of the conserved influenza matrix protein 2 [M2e], which has been found to induce heterosubtypic immunity, was fused to HSP70359-610 or C-terminus of Mycobacterium tuberculosis HSP70 [HSP70c] in pcDNA3.1 vector [pcDNA/M2e-HSP70c] and then encapsulated into a derivative of chitosan, N-trimethyl chitosan [TMC]. After encapsulation of the plasmid, physical properties of the particles were investigated using Zetasizer[R] 3000 the particles were then administered through the intranasal delivery in BALB/c mice. It was found that the particles had a size ranging between 90-120nm and positive surface charge. The intranasal immunization with M2e-HSP70c+TMC in BALB/c mice significantly induced higher M2e specific IgG than those induced in control groups [pcDNA/M2e-HSP70c without TMC, pcDNA/M2e, bearing M2e alone, and PBS]. The present study showed that the encapsulation of M2e/ HSP70c into N-trimethyl chitosan [TMC] could strongly induce the humoral immune response against the M2e-HSP70c plasmid without lowering the adjuvant efficacy of HSP70c

Simultaneous determination of losartan and hydrochlorothiazide in pharmaceutical preparations by derivative and ratio derivative spectrophotometry

Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin n receptors. Hyzaar is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, and multisyringe chromatography. UV-V is spectra of standard solutions of losaratan and hydrochlorothiazide were prepared separately and together in combination with various concentrations of the drugs. To determine these two drugs simultaneously without any preliminary treatment, losartan was determined by ratio derivative Spectrophotometry at third derivation with ? lamda = 10 nm at 246.3 nm, and hydrochlorothiazide was determined at first derivation with delta lamda = 5nm at 334.4 nm. This method was used to determine the two drugs in real samples of tablets. The method had a good linearity in the concentration range studied [r > 0.999]. Precision of the method revealed that RSD% was lower than 2.10 and 1.79 for losartan and hydrochlorothiazide, respectively. Accuracy of the method on the basis of error% was lower than 3.3% for losartan and 2.3% for hydrochlorothiazide. Based on the validation results, it could be concluded that the method was reliable and valid for determination of the drugs in their preparations. Real sample analysis showed that tablets had 84.9% hydrochlorothiazide and 92.6% losartan compared to label amount of the drugs. Results depicted a simple, valid, inexpensive and reliable method for simultaneous determination of the two drugs in pharmaceutical preparations applicable to the quality control laboratory of pharmaceutical industries

Longer years of practice and higher education levels promote infection control in Iranian dental practitioners

Infection control is one of the primary responsibilities of dental health care personnel. The purpose of this study was to evaluate whether the infection control practices of Iranian dentists and dental nurses working in governmental dental health care centers were influenced by their educational level and years of practice. This cross-sectional analytical study was completed in 2009, and it included 63 Iranian dental practitioners. Infection control knowledge was evaluated with a self-administered questionnaire, and infection control practices were evaluated with a checklist of questions by observation with one researcher. The dental practitioners in Mashad had a low level of infection control knowledge. Dental personnel with a higher educational level had significantly greater knowledge than those with less education. Additionally, dental personnel who had more years of practice had a greater knowledge of infection control. Since dental practitioners working in Mashad governmental dental health care centers with fewer years of practice and less educational level had a low level of infection control knowledge, we recommend a continuing educational program for this group and dental nurses

[Pattern of diet and supplement consumption among multiple sclerotic patients pre and post diagnosis and their attitudes toward the effects of these parameters on disease progression]

Multiple Sclerosis [MS] is one of the central nervous system white matter disorders, with variable prevalence in various districts. Some researches proposed the probable effects of diet as a risk factor in the etiology and control of MS due to its variety of patterns in diverse cultures and regions. Determination of the MS patients' dietary habits, before and after diagnosis of the disease and their attitude toward the effect of dietary parameters on the disease progression. In this cross-sectional study, A total of 166 confirmed MS patients referred to Tabriz MS society during 2005 to 2006 were assessed by a pretested questionnaire composed of 3 sections of questions about demographic informations, dietary habits pre and post disease diagnosis, weight and appetite changes and also changes in dietary patterns after diagnosis. Data were analyzed by t-student test and qi2 in SPSS version 16. A total of 122 women and 44 men participated with the mean age of 31.97 +/- 9.21 years, and the mean age of diagnosis 28.33 +/- 8.84 years, in this study. As revealed, 79.8% of the patients didn't change their dietary patterns mainly because of their inattention to probable effect of nutrition on symptoms of disease in 80% of cases. There was a significant change in the type of using oil that reduced the disease severity among 50% of the patients. Also, there was a significant increase in the usage of dietary supplement and fish oil and a significant decrease in tendency toward egg, sugar, and pickles, following the disease. The patients suggested that fruits, milk, olive and its oil, vegetables, fish and nuts are sequentially alleviating the symptoms but pickles, hot [chilli] foods, confectionary products, fried foods, conserved food and red meat aggrevating the symptoms. From patients' viewpoints, dietary patterns and supplements are somehow effective on the symptoms of multiple sclerosis

Association between modifiable lifestyle factors and inflammatory markers in patients with metabolic syndrome

There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. We carried out a cross-sectional study of 195 patients with metabolic syndrome. Data on nutritional intake, physical activity level and smoking habits were collected through a questionnaire. Weight and body composition were determined and C-reactive protein and interluekin-6 concentrations were measured. C-reactive protein level had a significant association with body mass index [r = 0.18], adiposity [r = 0.23], smoking [r = 0.20], carbohydrate intake [r = 0.19] and saturated fatty acid [r = 0.20]. Interluekin-6 concentration was significantly correlated with dietary carbohydrate [r = 0.15], saturated fatty acid [r = 0.15] and glycaemic load [r = 0.15]. No association was observed between physical activity level and inflammatory markers

Coronary artery disease and its risk factors status in Iran: a review

Coronary artery disease [CAD] is a leading cause of mortality, morbidity, and disability in the world. The high prevalence and morbidity associated with CAD in Iran is one of the most pressing health problems. We have reviewed the status of CAD and prevalence of its traditional and novel risk factors based on the published papers in recent years that may have an impact on the rate of CAD in Iran. Evaluation of current impact of metabolic syndrome in Iran was the other aim of this review, as it contributes to pathogenesis of coronary artery disease. We reviewed all PubMed indexed related studies. Some evidences from national articles which were published by the Ministry Of Health and Medical Education Research Council Certified Medical Journals of Islamic Republic of Iran were also included. The prevalence of CAD, coronary risk factors and metabolic syndrome in Iran is higher than Western countries and similar to some Middle East countries. There are limited data with regard to novel coronary risk factors in Iran. Primary and secondary prevention of CAD including life style modifications and dietary interventions strongly recommended in Iranian population

Microlithiasis and Nephrolithiasis among infants: Is it a new phenomenon?

Although nephrolithiasis is a rare but a serious problem for children's health, recent data has showed that the prevalence of pediatric nephrolithiasis has increased in both developed and developing countries. North and West of Iran, as a country located in Afro-Asian stone-forming belt, has the highest incidence for renal stones among adults. This study aimed to determine the incidence of microlithiasis and nephrolithiasis among infants in a city at North West of Iran. It was a cross-sectional study on infants aged less than one year old, diagnosed as patients with microlithiasis and nephrolithiasis, over three months period [since March 2010] who were referred to pediatrician in a city of East Azerbaijan province. Demographic data [age, sex], number of stones, size of stones, presence of hydronephrosis in kidneys, history of jaundice and family history of stone disease were recorded. Incidence of microlithiasis and nephrolithiasis was 0.04866 and 0.03244, respectively. Fever [30%] was the main cause of complication. Male to female ratio was 4:1, and 20% of our subjects had a positive history of nephrolithiasis in their first degree relatives. This area has the highest incidence of microlithiasis and nephrolithiasis. Emergent population-based and case-control studies are needed to report its incidence/prevalence of nephrolithiasis in other parts of the country as well as to find its etiology

comparison of prevalence of diabete and hypertension between rural areas of Fars and rural area of EMRO region

Since monitoring and evaluation of diabetes and hypertension in individuals/the population greatly contribute to improving both clinical care and following identification of disease in the region and even the country, and to manage prevent and control diabetes and hypertension and their risk factors, the goal of this study was to compare disease status in rural areas of Fars province and rural areas of the EMRO region. The current study is a descriptive-analytic cross sectional one that has been conducted in 2008 by randomized cluster sampling, based on data obtained from an extensive provincial screening plan for adults aged over 30 years in rural areas of Fars province. Based on these data, the prevalence of diabetes, hypertension and their risk factors were calculated and the relationship between diabetes and hypertension was determined by risk factors including age, sex, family history, and Ml using Chi square and t-test and SPSS software version 17 and Minitab version, prevalences in 15 is rural areas were compared with the ones in EMRO region countries. The prevalence of hypertension and diabetes rural areas of Fars province were calculated to be 21.8% and 11.14% respectively as compared with rural areas of EMRO region countries.The prevalence of diabetes was also lower on the average and the prevalence of obesity [BMI>30], was less than other countries in the region and Iran. In general, although, the prevalence obtained in this study was lower than other regional countries, raising a wareness in high rish groups affected public commitment to basic information transmitting to high risk classes of the society should be taken into account and commitment by the health system administration and the government to sustain monitoring of health, to ensure curtailing the burden of diabetes and hypertension and associated risk factors among countries of the region

In vitro potential of human bone marrow and umbilical cord vein mesenchymal stem cells to differentiate into insulin producing cells

Mesenchymal stem cells [MSCs] derived from bone marrow are multi potent cells that have the capacity to trans-different!ate into a variety of cell types including insulin islet cells. However the efficiency is low. The aim of this study is to explore the potential of Marrow and Umbilical cord vein MSC to differentiate into functional islet like cells in vitro. BM-MSCs and UC-MSCs were obtained from healthy donors and were cultured. MSCs with high CD90, CD73, CD105, CD44 and very low CD34 and CD45 expression were differentiated into Islet-like cells, under defined conditions. Insulin and c-peptide positive cells were evaluated with immune-florescence and insulin release after glucose challenge was tested by ELISA. QRT-PCR was done to detect expression of insulin, Glut2, Nkx6.1 and Nkx2.2 at mRNA level. Our results showed that only BM-MSC can be differentiated to insulin secreting cells. About 15.8% +/- 2.6 and 13.5% +/- 5.5 of cells were positive for insulin and c-peptide, respectively. Our results revealed that expression of Insulin and Glut2 upregulated 20 fold changes at mRNA level. However they were not functional when treated by different concentration of glucose. Our results showed that only Human BM-MSCs, compared to umbilical cord vein MSCs, are able to differentiate into insulin producing cells in vitro

Association between anthropometric measures and bone mineral density: population-based study

Osteoporosis is a major public health concern around the world. It has been shown that bone mineral density is correlated to anthropometric measures like height and weight, but this association may vary depending on ethnic and environmental factors. The aim of this study was to identify probable relations between anthropometric measures and bone mineral density. In this population-based study, we compiled the data collected from Iranian Multicenter Osteoporosis Study to assess the possible associations between different anthropometric indices and bone mineral density at femur and lumbar spine. The gathered data was analyzed using t-test and one way ANOVA. Data was available for 4445 subjects, consisting 1900 males [42.7%] and 2545 females [57.3%]. We observed statistically significant correlations between bone mineral density and height, weight, waist circumference, hip circumference, waist to hip ratio and body mass index [BMI]. Based on the result of linear regression modeling studies, BMI could be considered an independent predictor of bone mineral density. Iranian population shows similar measures compared to analogous studies in other populations. Lower weight should be carefully considered as a predisposing factor for bone loss and osteoporosis