clinical effects of topical metronidazole as adjunct therapy to subgingival debridement in adult periodontitis

The purpose of this investigation was to evaluate effect of local antibiotic therapy with metronidazole adjunctively to Scaling and Root Planning [SRP] mechanical or antibiotical treatment alone. This randomised double blind study was carried out in split-mouth design. Ten patients with moderate to severe adult periodontitis were selected. Each patient had to have at least 3 multi-root and 3 single-root nonadjacent teeth with a probing depth >/= 5[mm]. Randomly selected teeth were treated with application of 25% gel metronidazole [SRP+Elyzol]. A total of 141 site [