Résumé
Background and Objective: Resveratrol is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases. This study was done to evaluate additive effect of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice
Methods: In this experimental study, 56 Swiss Webster male mice were randomly allocated into 6 groups including negative control group [normal saline], positive control [imipramine [10 mg/kg/bw], experimental groups; trans resveratrol [10 mg/kg/bw], Imipiramine [10 mg/kg/bw] and mixtures [with ratio of 1:1 of resveratrol with imipramine [2.5 mg/kg/bw, 5 and 10 mg/kg/bw], intraperitoneally. The forced swimming test has been done for all groups. Through swimming of animals in water, the immobilization times of animals as depressive symptom were recorded
Results: The immobilization times significantly reduced in animals which were received imipramine 10 mg/kg/bw in compare to control group [P<0.05]. The immobilization times of animals were received resveratrol injection 10 mg/kg/bw with imipramine 10 mg/kg/bw was determined which it was significantly effective than imipramine10 mg/kg/bw, alone [P<0.05]. The antidepressant effectiveness of resveratrol injection 5 mg/kg/bw is similar to resveratrol [2.5 mg/kg/bw] with imipramine [2.5 mg/kg/bw]. is similar to resveratrol [2.5 mg/kg] with imipramine [2.5 mg/kg/bw] [P<0.05]. Also, antidepressant effect of intraperitoneal administration of resveratrol 10 mg/kg was significantly more than imipramine 10 mg/kg/bw [P<0.05]
Conclusion: According to additive effect of imipramine with resveratrol we can suggest resveratrol in combinations with other antidepressants to lower their doses and related side effects of chemical drugs