Résumé
Paget bone disease is a metabolic disease with unknown pathogenesis. We report the observation of two sisters with Paget disease, having a dyslipidemia past and one of them had diabetes mellitus. They both presented headache, vertigo and skull deformation. Paget bone disease diagnosis was held on phosphatase alkaline increase and radiologic investigations. Across these observations we remind clinical signs and diagnosis management of Paget disease. We discuss one etiology of this pathology, that may be genetic. Association of Paget disease and diabetes mellitus has been reported in one case
Sujets)
Humains , Femelle , Maladie de Paget des os , Fratrie , Dyslipidémies , Diabète , Phosphatase alcaline , Céphalée , Vertige , Maladies métaboliques/génétiqueRésumé
C-reactive protein [CRP] is an inflammation protein. It is also a cardiovascular prognosis marker. It may direct physician in primary prevention of the diabetes' degenerative complications. We released a prospective study in diabetics followed at the extern consultation of internal medecine in Ariana Mahmoud El Matri Hospital. We excluded all patients presenting infectious, inflammatory or tumoral disease and those receiving treatment interfering with CRP. The method used in our hospital for measuring CRP was qualitative and semi-quantitative agglutination test. 35 patients were included in our study. 22 women [62.9%] and 13 men [37.5%]. The medium age of diabetes was 5 years. Only one patient had a CRP superior to 6 mg/ [24mg/l]. The statistic study didn't find any relationship between CRP and glycemia or HbAIC. In our study, the qualitative measure of the CRP didn't permit to predict the risk inherent in diabetes. However, recents studies using ultrasensible technic of CRP measure, showed a narrow correlation between the balance diabetes [Hb A1C] and the CRP. It is imperative to use the quantitative measure of this protein to limit arterial damage
Sujets)
Humains , Mâle , Femelle , Protéine C-réactive , Système cardiovasculaire , Études prospectivesSujets)
Humains , Mâle , Femelle , Fructose , Hémoglobine glyquée , Analyse statistique factorielle/méthodesSujets)
Humains , Mâle , Femelle , Kyste épidermique/étiologie , Myélographie/méthodes , TomodensitométrieRésumé
About a retrospective study of 26 children who presents juvenile chronic arthritis, the authors studies their assessment according month of year. They show that in the majority of cases, it occurs during great climatic variations period when we note a rescrudescence of viral infection incidence. This study suggested the role of viral agent in the pathogenic of this disease