[Bunium persicum[black caraway] of Yazd Province: chemical assessment and evaluation of its antioxidant effects]

Medicinal plants are valuable natural resources that are nowadays known as safe pre-materials for drug industries in the advanced countries. Black caraway is one of the most important and economical medicinal plants that can be grown naturally in some regions of Yazd province. The essence of the plant are used in treatment of diarrhea, dyspepsia, fever, flatulence, stomachache, hemorrhoids, hiccoughs, as an antihistaminic and more numerous uses in medicine industries. This plant shows several therapeutic effects on digestive and urinary tract disorders and is well known as an anti-convulsant, anthelmintic, anti-asthma and antidyspnic drug in Iranian traditional medicine. Bunium Persicum oil is capable of suppressing the initial stage of an inflammatory process. Also, this plant is used for culinary purposes and for flavoring foods and beverages. In this research, the fractionization of seed essence was done by GC method and the compounds were recognized. The DPPH test was used for estimating anti oxidant effects and the Follin-Ciocalteu method was used for estimating quantity of phenol compounds. The results revealed that- gammaTerpinene had the highest percentage in the essence of the native black caraway of Yazd province. Also, the antioxidant test showed the high antioxidant effect of the native black caraway of Yazd province with an IC50 of 2.85 microg.mg-1 and the phenolic component percentage of 117.09mg.g1. This result was much higher than previous similar studies about black caraway

[Status of inheritance pattern of blindness in blind people supported by yazd province's welfare organization]

It is estimated that 148 million people worldwide, the vast majority of them in developing countries, are suffering from blindness or severe visual disorders. Understanding of the different kinds of blindness epidemiology and its inheritance pattern, genetic counseling and prenatal diagnosis are important factors in prevention and treatment of blindness. This survey was designed based on the above facts. This cross-sectional study was done on 109 blind people. The individuals were interviewed based on standard genetic counseling procedure. Blood samples were collected from the cases with inheritance pattern and then stored in a DNA bank. The data were analyzed by using SPSS software and ?2 test. From the total of 109 individuals, 73 were male [67%] and 36 were female [33%]. More than half of them [53.2%] were detectable in patients aged less than one year old. The most common cause of blindness and low vision was retinitis pigmentosa in 35 cases [32.1%] followed by globe dysgenesis in 18 cases [16.5%]. Consanguinity in different degrees and a positive familial history of blindness were detected in 76 and 66 patients respectively. There was no genetic pattern in ten pedigrees. In the rest, the genetic patterns were as follows 6.4% autosomal dominant, 33.9% autosomal recessive, and 11.1% X-linked recessive. In total the inheritance pattern was detected in 56 familial pedigrees which suggested single gene disorder with the relative frequency of 51.4% in the studied population. This study may help physicians and genetic counselors to understand the importance of genetic inheritance in blindness and low vision. In addition, we believe our findings will possibly shed a new light on the future plans involving diagnosis and prevention of visual blindness