Prophylactic effect of Nigella sativa on hepatic injury in rats

Thirty albino rats were used for investigation of the effect of Nigella sativa on paracetamol induced hepatic necrosis. The rats were divided into 3 equal groups. Nigella sativa protected rats against paracetamol and carbon tetrachloride hepatic injury evidenced by improvement of the histopathological changes and normalization of the biochemical changes induced by either paracetamol or CCL4

Human T-lymphotropic viruses [HTLVs] in mycosis fungoides

The direct or indirect involvement of retroviruses with the development of leukaemia/lymphoma has been well established in animals and human.Mycosis fungoides, a rare form of cutaneous T-cell lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T-cell leukaemia, which is associated with human T-cell leukaemia/ lymphoma virus type I [HTLV-1] infection. We have searched for HTLV-1, HIV-1 and HIV-2 antigens in the skin lesions and the antibodies in the sera of 3patients with mycosis fungoides. In one patient the skin lesion expressed HTLV-1 related antigen and by PCR we could detect HTLV-1 specific DNA in PBMCs of this patient this result could support the causative role of HTLV-1 in mycosis fungoides