Comparison the efficacy of cefazolin plus gentamicin with cefazolin plus ciprofloxacin in management of type -IIIA open fractures

The optimal antibiotic regimen is still controversial in open fractures. The purpose of this study was to evaluate the efficacy of two different antibiotic regimens in management of type III-A open fractures. From January 2001 to January 2008, patients with type IIIA open fractures admitted in Shahid Beheshti Hospital Affiliated to Babol University of Medical Sciences were enrolled. Patients randomly received cefazolin plus gentamicin [group I] or cefazolin plus ciprofloxacin [group II]. Both regimens were administered for 3 days. All patients were followed for 3 months. The efficacy of both regimens was compared. One hundred-forty eight and 153 patients were treated in group I and II, respectively. The mean age of the patients treated in group I was 36.96 +/- 14.4 and in group II was 36.93 +/- 13.51 years. The rate of deep infection in group I was 5.4% and in group II was 6.5%. The efficacy of regimen I was 94.6% and regimen II was 93.5%. Cefazolin plus gentamicin, or cefazolin plus ciprofloxacin both can be successfully used for prevention of infection in type IIIA open fractures

role of hygienic behavior in incidence of urinary tract infection among pregnant women referred to health center [Babol; 2002-2004]

The urinary tract infection [UTI] is a common problem in pregnant women. Since, UTI is caused by bacteria in the stool, hygienic behavior may affect the risk of contracting UTI. The purpose of this study was to determine the relationship between hygienic behavior and incidence of UTI in pregnant women. This case-control study was performed on 250 pregnant women from 2002-2004. One hundred pregnant women from five health centers of Babol University of Medical Sciences for prenatal care, with a diagnosis of UTI by means of positive urine culture [as case group] were compared with one hundred fifty pregnant women [as control group]. Both groups were matched according to age and social, economic, educational status and parity. Patients with recurrent UTI, chronic diseases like diabetis and sickle cell anemia and consumption of immuno suppressive and antibiotic drugs were excluded from this study. Data was analyzed by SPSS. P<0.05 was considered significant. Escherichia coli was the etiologic agent in 83% of cases. Odd ratio for any of the above variables were determined and risk factor for UTI were as follows: for sexual intercourse >/= 3 times per week [OR=5.62], recent urinary tract infection [OR= 3.27], washing of genital pre coitus [OR= 2.16], washing of genital post coitus [OR= 3.89], voiding post coitus [OR= 8.62], washing of genital from back to front [OR= 2.69]. Mean scoring hygienic behaviors in case and control group were 19.9 +/- 3.65 and 23.44 +/- 3.43, respectively. Hygienic habits and sexual behavior may play a significant role in the pregnant women with UTIs, with a positive bacterial urine culture, but evacuating of bladder after coitus was the most strongly associated variable