Uses of 2- [beta-carboxyethyl] -4-chloroquinazoline as a binding in synthesis of some heterocyclic systems of expected biological activity

In continuation of our studies on the synthesis of heterocyclic systems of biological interest[1-7], the synthesis of 2-[beta-carboxyethyl]-4-chloroquinazoline [I] which provides easy access to polycyclic systems of potential biological interest is herein reported. Compound I was obtained via the interaction of 2-[beta-carboxyethyl]- quinazolin-4-one[8]' with a mixture of phosprous pentachloride/ phosphorus oxychloride. The infrared spectrum of compound I shows sharp bands characteristic for quinazoline moiety[9]' in region [1630-1620,1580-1570 and 15156-1480] cm[-1] beside the upsilon C = O of acid at 1715 cm[-1] and upsilon OH of carboxylic acid [3500-3300 cm[-1] kelated band]

Utilities of 4- [4'benzyl phenyl] 6-Arylpyrimidine-2-thiones for the synthesis of biologically active condensed and non-condensed heterocycles

The pyrimidine nucleus has been employed as a basis for the synthesis of chemotherapeutic agents and a large number of its derivatives have been reported to possess various biological properties such as antitumour, antimalarial, antiinflammatory, antibacterial and other pharmacological properties[1-5] Prompted by these observations pyrimidine-thione I is used now as a building block for the synthesis of new condensed and non-condensed heterocyclic compounds

Thermolysis and photolysis of 7-methyl-2,2,5-triphenyl 1-oxa-5,6-diaza spiro- [2,4] - hept-6-ene-4-one

It was stated previously that 7-methyl-2, 2,5-triphenyl-l-oxa-5,6-diaza spiro-[2,4]-hept-6-ene-4-one undergoes pyrolytic fragmentation at 140 degree for 1 hr to give an oil. GC/MS investigation of the pyrolyzate oil revealed the presence of nineteen fragments [1]