Novel 5,6,7,8-Tetrahydronaphth-2-yl heterocycles of possible biological activity

2-cyclocondensation 2 underwent with different alpha-cyanocinnamonitriles to give the corresponding poly substituted pyran derivatives 3[a-d] which upon treatment with carbon disulphide gave the pyranopyrimidindithione derivatives 4[a-c]. Also, treatment of 2 with different aldehydes afforded the corresponding cinnamonitrile derivatives 5[a,b] which upon reaction with 3-methyl-1- phenylpyrazol-5-one gave the corresponding pyranopyrazole derivatives 6[a,b]. Moreover imidazo [2,3-b] thiazoles 8[a,c]; 1,2,3- thia- or 1,2,3- selena-diazoles 10[a,b]; thiazolidinones 16[a,b] and benzoxazin-4-one derivatives 18[a,b] derivatives were synthesized starting with 2-acetyltetralin. Compounds 3[c],11[b],12 were tested as antibilharzial agents and compounds 6[a],8[a] as antileukemia agents in experimental animals. Some of these compounds showed moderate activity

Synthesis of N, N'-bis [N-4-N-methylcarbamyl-oxymethylthioxanthen-9-on-1-yI aminoethyI] piperazine of possible antitumor activity

N,N'-bis [N-[4-hydroxymethylthioxanthen-9-on-1-yl] piperazine and its N-methylcarbamate derivative have been synthesized. The compounds are considered a combination of two molecules of the antischistosomal drug, hycanthone. The two compounds are possibly active as antitumor as well as antischistosomal

Synthesis of some new 4-substituted anilionowuinolines of expected biological activity

In this study, new 7-chloro-4-[p-[4-aryl-3-cyano-2-imino[1H]pyridin-6-yl]- anilino]quinolines[2a-e], 7-chloro-4-[p-[4-aryl-3-cyano-2-oxo[1H] pyridin- 6-y1]-anilino]quinolines [3a-f], 7-chloro-4-[p-[4-aryl-3-cyano]-2-thioxo [1H] pyridin-6-yl]anilino]quinolines [4a-c] and also semicarbazone and substituted thiosemicarbazones [5a-d] were synthesized. The antimicrobial evaluation of some of the new compounds was carried out. The results of the study were given

Synthesis of some new isoxazolidin-3,5-diones, pyrazolidin-3,5-diones and barbituric acids of expected antimicrobial activity

New isoxazolidin-3,5-diones[3,8], pyrazolidin-3,5-diones[4a,b,9] and other related products of barbituric acid 5a, 10 and thiobarbituric acids 5b were synthesized using the malonic acid diethyl ester 2 and 7 as intermediates. The evaluation of the antimicrobial activity of these newly compounds was carried out. The results of the study were given

Synthesis of some new benzimidazole derivatives with evaluation of their antimicrobial activity

A series of N1-p-[2-benzimidazoylamino] benzoyl] N2-arylidene hydrazine [3a-e], pyrazolone 4 pyrazole 5, carbothioamide 6a-c, 1,3,4-thiadiazol 7 and 1,3,4-triazoles 8 were prepared. Some of the new compounds showed considerable antimicrobial activity against Gram +ve, Gram -ve bacteria, yeast and fungi

Synthesis of some novel benzimidazole derivatives as antimicrobial agents

Synthesis of 2-[p-[5-aryl-1-[H or phenyl]-delta2 pyrazolin-3-yl] anilino] benzimidazoles [4a, b], 2-[p-aryl-2-isoxazolin-3-yl] anilino] benzimidazole [5], 2-[p-[6-aryl-2-[oxo or thioxo]-1,2,5,6- tetrahydropyrimidin-4-yl] anilino] benzimidazoles [6a,b] and 2-[p- sulfamoylanilino] benzimidazoles [7a-g] were synthesized. The new compounds showed inhibitory effect against the growth of Gram +ve, Gram -ve bacteria, yeast and fungi

Synthesis of some new benzimidazole derivatives as antimicrobial agents

Synthesis of 2-[p-4-aryl-3-cyano-2-oxo[IH] pyridin-6-yl] anilino] benzimidazoles [2a-g] and the 2-[p-[4-aryl-3-cyano-2-imino[IH] pyridin-6-yl] anilino] benzimidazoles [3a-g] were obtained in one step reaction between the 2-[p-acetylanilino] benzimidazole [1] with ethyl cyanoacetate and/or malononitrile and the appropriate aldehydes in the presence of ammonium acetate. The new compounds showed considerable antimicrobial activity against Gram +ve, Gram -ve bacteria, yeast and fungi