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1.
J. appl. oral sci ; 27: e20180635, 2019. tab, graf
Article Dans Anglais | LILACS, BBO | ID: biblio-1012524

Résumé

Abstract Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. Objective The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. Methodology Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). Results Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). Conclusion Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.


Sujets)
Humains , Mâle , Femelle , Adulte , Jeune adulte , Langue/microbiologie , Microbiote , Acétaldéhyde/analyse , Bouche/chirurgie , Valeurs de référence , Bactéries/isolement et purification , Bactéries/génétique , Langue/métabolisme , Candida/isolement et purification , Consommation d'alcool/métabolisme , ARN ribosomique 16S/analyse , ARN ribosomique 16S/métabolisme , Fumer/métabolisme , Études transversales , Enquêtes et questionnaires , Statistique non paramétrique , Charge bactérienne , Japon , Acétaldéhyde/métabolisme , Bouche/métabolisme
2.
J. appl. oral sci ; 23(1): 64-70, Jan-Feb/2015. tab, graf
Article Dans Anglais | LILACS, BBO | ID: lil-741599

Résumé

Objective Acetaldehyde is the first metabolite of ethanol and is produced in the epithelium by mucosal ALDH, while higher levels are derived from microbial oxidation of ethanol by oral microflora such as Candida species. However, it is uncertain whether acetaldehyde concentration in human breath is related to oral condition or local production of acetaldehyde by oral microflora. The aim of this pilot study was to investigate the relationship between physiological acetaldehyde concentration and oral condition in healthy volunteers. Material and Methods Sixty-five volunteers (51 males and 14 females, aged from 20 to 87 years old) participated in the present study. Acetaldehyde concentration in mouth air was measured using a portable monitor. Oral examination, detection of oral Candida species and assessment of alcohol sensitivity were performed. Results Acetaldehyde concentration [median (25%, 75%)] in mouth air was 170.7 (73.5, 306.3) ppb. Acetaldehyde concentration in participants with a tongue coating status score of 3 was significantly higher than in those with a score of 1 (p<0.017). After removing tongue coating, acetaldehyde concentration decreased significantly (p<0.05). Acetaldehyde concentration was not correlated with other clinical parameters, presence of Candida species, smoking status or alcohol sensitivity. Conclusion Physiological acetaldehyde concentration in mouth air was associated with tongue coating volume. .


Sujets)
Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Sujet âgé , Sujet âgé de 80 ans ou plus , Jeune adulte , Acétaldéhyde/analyse , Bouche/composition chimique , Langue/composition chimique , Acétaldéhyde/métabolisme , Candida albicans/isolement et purification , Études transversales , Éthanol/métabolisme , Microbiote , Respiration par la bouche/métabolisme , Respiration par la bouche/microbiologie , Bouche/métabolisme , Bouche/microbiologie , Enquêtes et questionnaires , Valeurs de référence , Facteurs sexuels , Statistique non paramétrique , Facteurs temps , Langue/métabolisme , Langue/microbiologie
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