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Braz. j. med. biol. res ; 36(12): 1653-1657, Dec. 2003. ilus
Article Dans Anglais | LILACS | ID: lil-350469

Résumé

The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.


Sujets)
Adolescent , Nouveau-né , Nourrisson , Enfant d'âge préscolaire , Enfant , Adulte , Adulte d'âge moyen , Humains , Multirésistance aux médicaments , Glycoprotéine P , Lymphocytes T , Facteurs âges , Sujet âgé de 80 ans ou plus , Cytométrie en flux , Colorants fluorescents , Rhodamine 123
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