Résumé
The objective of the present study was to determine if there is a relationship between serum levels of brain-derived neurotrophic factor (BDNF) and the number of T2/fluid-attenuated inversion recovery (T2/FLAIR) lesions in multiple sclerosis (MS). The use of magnetic resonance imaging (MRI) has revolutionized the study of MS. However, MRI has limitations and the use of other biomarkers such as BDNF may be useful for the clinical assessment and the study of the disease. Serum was obtained from 28 MS patients, 18-50 years old (median 38), 21 women, 0.5-10 years (median 5) of disease duration, EDSS 1-4 (median 1.5) and 28 healthy controls, 19-49 years old (median 33), 19 women. BDNF levels were measured by ELISA. T1, T2/FLAIR and gadolinium-enhanced lesions were measured by a trained radiologist. BDNF was reduced in MS patients (median [range] pg/mL; 1160 [352.6-2640]) compared to healthy controls (1640 [632.4-4268]; P = 0.03, Mann-Whitney test) and was negatively correlated (Spearman correlation test, r = -0.41; P = 0.02) with T2/FLAIR (11-81 lesions, median 42). We found that serum BDNF levels were inversely correlated with the number of T2/FLAIR lesions in patients with MS. BDNF may be a promising biomarker of MS.
Sujets)
Adulte , Femelle , Humains , Facteur neurotrophique dérivé du cerveau/sang , Sclérose en plaques récurrente-rémittente/sang , Sclérose en plaques récurrente-rémittente/anatomopathologie , Marqueurs biologiques/sang , Études cas-témoins , Gadolinium , Imagerie par résonance magnétique/méthodesRésumé
Os autores relatam um caso de granuloma esquistossomatico de localizacao medular cujo diagnostico inicial foi de tumor intramedular sem caracterizacao nosologica.O resultado e diagnostico, apos exame histologico da peca cirurgica, bem como aspectos diagnosticos atraves de exames complentares e caracteristicas endemicas do processo sao discutidos
Sujets)
Adulte , Humains , Mâle , Maladies de la moelle épinière , Granulome , Schistosomiase , MyélographieRésumé
Os autores relatam um caso de meningeoma ectopico de calvario, submetido a tratamento cirurgico com boa evolucao. Comentam alguns aspectos referidos na literatura, ressaltando as caracteristicas radiologicas. Justificam o presente relato pela infrequencia do mesmo, bem como pelo bom prognostico quando submetido a tratamento adequado