Phytochemical constituents and antioxidant activities of some plants commonly used in Indian traditional diet.

Dietary antioxidants are known to play a key role in combating the cellular oxidative stress imposed by the free radicals as well as in inhibiting the undesirable changes in nutritional quality of food. The present investigation was designed to evaluate the in vitro antioxidant properties and the major phytoconstituents of some plants regularly used in Indian traditional diet. Methanolic extracts of Costus igneus, Foeniculum vulgare, Leucas aspera, Muntingia calabura, Physalis minima and Sauropus androgynus were prepared by maceration. Antioxidant activities were assessed using phosphomolybdenum method and ferric reducing power assays. Total antioxidant activities of methanolic extracts ranged between 4.89 μg/ml to 46.0 μg/ml ascorbic acid equivalents for the tested extracts. F. vulgare methanolic extract possessed maximum antioxidant activity. This investigation revealed the potential antioxidant activity of the tested extracts and therefore, their use in the regular diet will be helpful in combating free radical associated health effects. Also, antioxidant rich formulations can be prepared using these plant materials.

Cancer drugs inhibit morphogenesis in the human fungal pathogen, Candida albicans

Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs.