Résumé
To determine the changes in placentae in pregnant ladies suffering from pregnancy induced gestational diabetic mellitus. A cross sectional study. Sampling was done of the patients from the OPD's of Taluka hospital Hala and basic health unit Hala old, with collaboration of department of Anatomy, Baqai Medical University, Karachi from Jan-2011 to June 2011. Placentae were preserved in 10% formalin of Merck Company and studied macroscopically as well as microscopically. These features include shape, size, and site of attachment of umbilical cord, central thickness and diameter [in centimeter, diameters] and weights [in grams] of fully developed placentae. Microscopic feature will include infarction, placental haemorrhage, villous edema, hyper vascularity and increase production of syncytial epithelial knots. Central thickness [Mean +/- S.D +/- SEM] diabetic placenta 3.8 +/- 1.15 +/- 0.21 were significantly high [p<0.01] as compared normal placenta. In diabetic placenta [Mean +/- S.D +/- SEM] of diameter 34.5 +/- 7.93 +/- 1.45 and weight 1478.8 +/- 699.6 +/- 127.7 were significantly [p<0.01] high as compared to normal placenta diameter 21.1 +/- 3.37 +/- 0.62, weight 557.8 +/- 33.85 +/- 6.18. Gestational diabetes causes significant morphological changes in placenta that affects fetal and maternal wellbeing. This study is helpful for those who are concerned for mother and child health