RÉSUMÉ
Malignant tumours affecting the eyelid mainly include basal cell carcinoma. Non-Hodgkin抯 lymphoma may occur in almost any part of the body and should be considered in the differential diagnosis of extra lymphoid tumours. Non- Hodgkin抯 lymphoma of the eyelid is rare. Rare diseases should be considered in differential diagnoses because they have the tendency for rapid systemic involvement and they may require treatments that are different from the other common diseases. Basal cell carcinoma occurs most frequently at sun-exposed sites, most commonly in the head and neck regions. The aim of any therapy selected for BCC treatment involving the head and neck is to ensure complete removal, functional preservation, and a good cosmetic outcome. Here, we reported a case of a 70-year-old female with non-Hodgkin lymphoma of eyelids followed by basal cell carcinoma of the nose treated with multimodality approach.
RÉSUMÉ
Nasopharyngeal carcinomas (NPCs) are one of the most chemo- and radio- sensitive cancers of the head and neck region. It differs from other head and neck cancers in terms of signs and symptoms, treatment response and overall survival. Surgery is not the preferred treatment option, with chemoradiation being the treatment of choice, with an excellent local control rate, prognosis and overall survival. But the management of recurrent NPC is quite challenging and the treatment options available includes re-irradiation, chemotherapy, brachytherapy or surgery in rare cases. Re-irradiation in case of recurrent NPC is very difficult due to the already irradiated tissue in the radiation path, but re-irradiation with brachytherapy is an excellent treatment option for giving further doses of radiation to the nasopharynx in cases of recurrence or residual disease, by taking in consideration the already irradiated area and the radiation dose given before, and achieving a good local control rate and overall survival.
RÉSUMÉ
Background: Nasopharyngeal carcinoma (NPC) is relatively rare worldwide but exhibits a higher prevalence in specific geographic regions, particularly Southeast Asia and the North-Eastern states of India. In this study, we present a comprehensive analysis of a decade抯 worth of data involving 117 patients with NPC at the Regional Institute of Medical Sciences, Imphal, Manipur, India. Methods: We retrospectively reviewed data from 117 newly diagnosed NPC patients spanning from 2012 to 2022. Key demographic parameters such as age, gender, presenting symptoms, and disease stage were meticulously documented. Survival outcomes were assessed using Kaplan-Meier survival curves. Results: Our analysis encompassed 117 patients. The median age at presentation was 54 years. Undifferentiated carcinoma emerged as the predominant histological subtype. Notably, patients with type 1 keratinizing carcinoma, cranial nerve involvement, and advanced disease stages exhibited significantly poorer overall survival outcomes. Conclusions: This retrospective analysis of nasopharyngeal carcinoma in the North-Eastern region of India highlights the critical significance of implementing early detection and intervention strategies for NPC in this specific geographical area, with the potential to improve patient outcomes.
RÉSUMÉ
Background: Stomach cancer is the fifth most common cancer in the world, which generally presents in advanced stage and have poor prognosis. Methods: Retrospective study including 101 cases was done at the Regional Cancer Centre in North East India from January, 2018 to December, 2022 on the clinical, pathological and treatment aspects of stomach cancer. Results: Median age of diagnosis was 59 years, with high male: female ratio. Most common risk factor was tobacco smoking and chewing. Most common symptom was pain abdomen followed by nausea or vomiting. Antrum was the most common tumor location, and gastric outlet obstruction was present in 10.9% patients. Histologically, all patients had adenocarcinoma, with metastasis found in 47 patients. Out of the 101 patients enrolled in the study, 50 patients were treated with curative intent and the remaining 51 patients were treated with palliative intent. Patients were treated with surgery, preoperative/ adjuvant/ palliative chemotherapy and/or curative/ palliative radiotherapy. Conclusions: This study showed tobacco use as an important risk factor for stomach cancer. Majority of our patients were diagnosed at an advanced stage, thus having poor prognosis. Hence, avoidance of risk factors, early detection of signs and symptoms, and aggressive treatment with surgery, chemotherapy, and/ or radiotherapy is required for management of stomach cancer.