Role of transferrin and ceruloplasmin as endogenous antioxidant in the pathogenesis and promoton of late diabetic complications

The serum antioxidant, ceruloplasmin and transferrin were estimated in forty diabetic patients that either suffer only from hyperglycemia [n = 20] or from hyperglycemia and late diabetic complications [n = 20]. Glycohemoglobin percentage was determined to test the degree of control of diabetic state. It was found that serum ceruloplasmin was significantly higher in diabetics with late complications than in diabetic without it. On the other hand, serum transferrin was significantly lower in diabetic with late complications than in diabetic without. Glycohemoglobin percentage was comparable in both groups of patients although it was still higher than that recommended percentage for good controlled diabetes