Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey.

Non-alcoholic fatty liver disease (NAFLD) is a common clinical condition which is fast assuming importance as a possible precursor of more serious liver disorders, including cirrhosis of the liver and hepatocellular carcinoma. There are no data in the published English literature on the prevalence of NAFLD in India. The present study was performed to assess a prevalence of NAFLD by ultrasonography in a general population in coastal eastern India. Asymptomatic, apparently healthy attendants accompanying the patients attending the Gastroenterology outpatient were subjected to abdominal ultrasonographic examination for the presence of fatty liver; individuals who gave a history of alcohol abuse were excluded from the study. The subjects of the study comprised 159 apparently healthy attendants, who underwent ultrasonography. Fatty liver was diagnosed by ultrasonography in 39 of these 159 persons (24.5%). Fatty liver was seen more commonly in males (26.9%) than in females (13.8%). Persons with ultrasonographic fatty liver had a higher body mass index (BMI) (mean 25.9 +/- 4.17 kg/m2) than persons without fatty liver (mean 22.1 +/- 3.27 kg/m2) (p<0.001). The estimated prevalence of NAFLD in an unselected apparently healthy and asymptomatic population as detected by ultrasonography in our study was found to be 24.5%. This is similar to the prevalence rate published from the west. However, contrary to figures from the west, males appeared to have a greater predilection for fatty liver than females in our study. NAFLD is perhaps as common in developing world as in the developed countries despite a lower prevalence of obesity. Indian males may have a greater genetic predisposition to developing NAFLD.

Cryptococcal lymphadenitis and meningitis in human immunodeficiency virus infection--a case report.

Cryptococcal meningitis (CM) is the commonest life threatening opportunistic fungal disease in Human Immunodeficiency Virus (HIV) infected individuals. But there are very little reports of lymphadenopathy along with cryptococcal meningitis, although cases of pulmonary, Intestinal, Bone marrow and retinal involvement have been described earlier. Here we report a case of cryptococcal meningitis associated with generalized lymphadenopathy and hepatosplenomegaly.

Fine needle aspiration as a primary diagnostic procedure of breast lumps.

Two hundred and sixty-seven patients from the ages between 17 to 70 years with breast lumps attending the Cytology Clinic of the Out-patients Department and Cytology Section of the Department of Pathology, M.K.C.G. Medical College, Berhampur (Orissa), were subjected to Fine-Needle Aspiration Cytology (FNAC). Sixty-four patients were discarded from study because of non-availability of biopsy specimens and unsuitable smears. When cytological results were compared with those of histological sections, 100 per cent correct diagnosis was made in chronic mastitis and lobular carcinoma, 94.24 per cent in infiltrating duct carcinoma and 84.60 percent in duct papilloma and with the maximum over diagnosis to the tune of 14.75 per cent was found in fibro-adenoma. An overall correct diagnosis was made in 88.67 percent of cases by FNAC.