Histopathological finding of vesiculobullous lesions of skin in relation to their clinical presentation: Prospective study from a tertiary care center

Background: Vesiculobullous disorders (VBDs) are extant with diverse clinical manifestations. Vesicles and bullae are fluid-filled cavities present within or beneath the epidermis. They are autoimmune blistering disorders in which autoantibodies are directed against target antigens present in the epidermis and dermo-epidermal junction. Objective: Evaluation of the various clinicodemographic profile of patients with a pattern of distribution (subtypes) of VBDs of the skin and assess the association between clinical aspects and histological changes in vesiculobullous lesions of the skin. Materials and Methods: The study material constituted 93 cases of VBDs out of 936 skin biopsies reported over two and a half years (January 2016 to June 2018) from the tertiary care center. A detailed history of the patients was taken, and a complete physical and dermatological examination with findings including clinical diagnosis was recorded. Histopathological examination (incisional/excisional/punch biopsy) was done in each case. The clinico-demographic evaluation was done and the results were correlated with histopathological findings. Results: Vesiculobullous lesions constituted 10.06% of all skin biopsies. The majority of cases were of pemphigus vulgaris (PV) 30 (32.25%) followed by 16 (17.2%) of bullous pemphigoid. In 83 cases (89.24%) histopathology findings were consistent with clinical diagnosis. Out of 34 cases that were diagnosed clinically as PV , the histopathological study proved 30 cases (88.23%) as PV. Conclusion: Vesiculobullous lesions of the skin are a heterogeneous group of disorders. It is essential to differentiate each pattern of subtype based on clinical examination and histopathological findings. Histopathological diagnosis with clinical correlation plays a major role in arriving at the diagnosis.

Seroprevalence of Transfusion Transmissible Infections among Blood Donors at a Tertiary Care Teaching Hospital in Central India

Introduction: Blood transfusion is both a life saving measurein many medical and surgical emergencies and a source oftransfusion transmitted infections. So a provision for strictcriteria in recruitment and deferral of blood donors mayimprove safe transfusion practice. The present study wasconducted to estimate the prevalence of transfusion transmittedinfections in voluntary and replacement donors at a tertiarycare teaching hospital in Indore, Madhya Pradesh,CentralIndia.Material and Methods: The present study was a 4 yearretrospective study from 2015 to 2018. Data was analyzedfrom blood bank records,pertaining to all donors who werescreened for HBsAg, Hepatitis C virus and HIV by usingappropriate methods.Results: A total of 45,704 Voluntary & replacement donorswere screened out of which 44,663 (97.72%) were males &1041 (2.27%) were females. The overall seroprevalence ofHBV & HCV was 1.29% & 0.072% respectively, while theprevalence of HIV was 0.076%.The prevalence rate washighest for HBV followed by HIV and HCV in decreasingorder. The overall seroprevalence of various TTI’s among thestudied donors was 1.43%.Conclusion: Blood is still one of the main sources oftransmission of infections like HIV, Hepatitis B and HepatitisC. Extensive donor selection and screening procedures willhelp in improving the blood safety.