Loading dose diazepam therapy for alcohol withdrawal state.

Two dose regimens of diazepam, conventional dose and loading dose, were randomly given for the treatment of alcohol withdrawal state in 21 and 20 male subjects, respectively. Total dose of diazepam in conventional and loading dose groups were 200 mg and 67 +/- 9.3 mg, respectively. Clinical response was comparable in both the groups. None of the subjects developed diazepam related side effects.