Neonatal lupus erythematosus presenting as multiple photosensitive annular plaques with skin atrophy

Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an infant of NLE presenting at birth with multiple annular erythematous plaques with skin atrophy involving the face, head, and upper trunk. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extranuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease.

Treatment of Infantile Haemangiomas with 585nm pulsed dye laser

Haemangiomas usually develop within the first few weeks of life, most regressing spontaneously before the age of 7 to 10 years. Some may ulcerate or compromise a vital function, in which case systemic corticosteroids, surgery or radiotherapy may be helpful. All of these treatment modalities are associated with significant morbidity. Treatment with 585nm flashlamp pulsed dye laser is safe and effective in the management of ulcerated and superficial proliferating haemangiomas. We report a retrospective review of 33 children under the age 12 months, who were treated at our centre with 585nm pulsed dye laser over a period of 4 years. Forty eight percent of these children presented with rapidly proliferating haemangiomas causing functional impairment, 40% with ulcerated haemangiomas and others for re-growth after stopping oral treatment. Patients were treated with the 585nm pulsed dye laser (fluence: 5.5-7J/cm2; spot size: 7mm and duration: 0.45s). Patients received treatment until the lesion was almost clear or until lesion failed to respond. All lesions ulcerated haemangiomas healed after an average 3 treatment. Both the physician and parental perception of improvement were analysed based on three parameters, which include reduction in redness, thickness and size. All the haemangiomas showed significant reduction in size, thickness and colour. Less than 1% of patients had atrophic scaring. We conclude that the flashlamp-pulsed dye laser may successfully prevent enlargement and promote involution of superficial haemangiomas with minimal adverse effect. Therapy is most appropriate for patients with ulcerated haemangiomas and haemangiomas at sites of potential functional impairment.

Efficacy and safety of tacrolimus ointment in patients with moderate to severe atopic dermatitis - Malaysian experience

Objectives To evaluate the efficacy and safety of tacrolimus ointment 0.1% in adult and 0.03% in pediatric patients with moderate to severe atopic dermatitis in Malaysia. Methods This is an open-labeled and single arm multi-center study. 36 adult and 37 pediatric patients were enrolled. Tacrolimus ointment is applied twice daily for four weeks. The primary efficacy outcome is based on the Physician’s Global Evaluation of Clinical Response (PG) at Week 4. The secondary efficacy outcomes are Eczema Area and Severity Index (EASI) score, changes from baseline in individual scores of signs and symptoms and body surface area affected and Patients Assessment of Treatment Effects. Results Overall success rate were 97.1% and 91.2% in the adult and pediatric groups respectively. The decline in EASI, percentage of total BSA affected and patient’s assessment of pruritus were significant (P<0.001). Of adults and pediatric patients, 97.2% and 75.7% respectively reported adverse effect. The most common adverse effect reported was skin burning sensation in 91.7% adult patients and pruritus in 67.6% pediatric patients. Conclusion Tacrolimus ointment 0.1% in adult and 0.03% in pediatric patients is effective for the treatment of moderate to severe atopic dermatitis in Malaysia.