Résumé
The chromosomal abnormality of Philadelphia chromosome is mostly seen in Chronic Myeloid Leukemia (CML). But it is observed that the Philadelphia chromosome (Ph), t(9,22), is the most common cytogenetic abnormality in adult patients with acute lymphoblastic leukemia (ALL), occurring in about 20% to 30 % of all cases. Patients with Ph-positive ALL have breaks in the minor breakpoint region, m?BCR (exons 1?2) lead to a short fusion proteins (p190) and is most frequently associated with Ph chromosome- positive ALL. They have an increased risk for central nervous system (CNS) involvement, an aggressive clinical course and poor prognosis. Historically, they had an inferior outcome when compared with their Ph-negative counterparts. Adult Ph+ patients achieve Complete Remission rates comparable to Ph? ALL patients with standard chemotherapy, but the remissions are short and survival poor. The addition of tyrosine kinase inhibitors (TKIs) including imatinib has dramatically improved outcomes. We are presenting this case report of t(9;22), p190 BCR-ABL1 positive ALL in an elderly female patient of south Gujarat.
Résumé
Background: Ovarian tumours are one of the major cause of gynaecological problems in females and present marked variation in their histological types. Relative frequency of these lesions is different for Western and Asian countries. Aims & Objective: This study was designed to find out frequency of various histological patterns of ovarian tumours in patients attending Pathology department of a teaching institute in Gujarat. Material and Methods: A retrospective – series study was conducted on 337 cases of ovarian masses, reported from January 2002 to December 2012. Results: Mean age of the subjects was 33.6 years, ranging from 8 to 70 years. In a total 337 cases of ovarian masses, 197 (58.46%) were non-neoplastic and 140 (41.54%) were neoplastic. Among neoplastic lesions, 77.14% (108/140) were benign, 3.57% (5/140) were borderline and 19.29% (27/140) were malignant. The commonest non-neoplastic lesion was luteal cyst (59/197) followed by simple serous cyst (56/197). The commonest malignant tumour was serous cystadenocarcinoma (11/27) followed by mucinous cystadenocarcinoma (5/27). The commonest borderline tumour was borderline serous tumour (4/5). Conclusion: Non-neoplastic lesions were more common than neoplastic lesions. Among neoplastic lesions benign tumours were common. The commonest benign tumour was serous cystadenoma and malignant was serous cystadenocarcinoma. The commonest non-neoplastic lesion was luteal cyst. Among histological types of ovarian tumours, surface epithelial tumours dominated the other types.