Résumé
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.
Sujets)
Administration par voie orale , Animaux , Condiments/effets indésirables , Curcuma , Femelle , Lésions hépatiques dues aux substances/étiologie , Souris , Microscopie électronique , Extraits de plantes/effets indésirablesSujets)
Accidents du travail , Adolescent , Adulte , Production d'anticorps/effets des médicaments et des substances chimiques , Enfant , Aberrations des chromosomes/effets des médicaments et des substances chimiques , Cyanates/intoxication , Catastrophes , Femelle , Intoxication au gaz/étiologie , Humains , Immunité cellulaire/effets des médicaments et des substances chimiques , Inde , Isocyanates , Mâle , Adulte d'âge moyenRésumé
Preliminary studies on the in vivo and in vitro interactions of 14C-metronidazole with macromolecules showed that the agent or its metabolite(s) can interact with nucleic acids and proteins in vivo. In vitro studies suggest that in absence of DNA synthesis trace amount of metronidazole does bind to DNA/protein and addition of metabolic activation system (from mouse liver) generates more reactive species from metronidazole.