Résumé
Background: vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules and patches. Researchers suggested that vitiligo may arise from autoimmune [AI], genetic, oxidative stress or neural causes. Zinc [Zn] and copper [Cu] are trace elements that are required in minutely small doses. The unique process of keratinization and melanin formation is enzyme-dependent and therefore could be influenced by trace elements deficiencies or excesses as trace elements are involved in enzymatic activities and immunologic reactions
Aim of work: this study aimed to detect the levels and roles of serum Zn and Cu in the pathogenesis of vitiligo
Patients and methods: our study included 50 vitiligo patients and 50 apparently healthy controls. Age of study groups ranged from 15 to 60 years and both sexes. Serum Zn and Cu levels were measured in each study group
Results: serum Zn levels were statistically significant lower in both the studied groups, but in vitiligo group they were much lower than the control group. Serum Cu levels were statistically insignificant higher in vitiligo group than the control group
Conclusion: there is a relationship between vitiligo and serum Zn. Further studies are needed to obtain better knowledge about effect of the trace elements in vitiligo patients
Résumé
Background: vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules and patches. Researchers suggested that vitiligo may arise from autoimmune [AI], genetic, oxidative stress or neural causes. Zinc [Zn] and copper [Cu] are trace elements that are required in minutely small doses. The unique process of keratinization and melanin formation is enzyme-dependent and therefore could be influenced by trace elements deficiencies or excesses as trace elements are involved in enzymatic activities and immunologic reactions
Aim of work: this study aimed to detect the levels and roles of serum Zn and Cu in the pathogenesis of vitiligo. Patients and methods: our study included 50 vitiligo patients and 50 apparently healthy controls. Age of study groups ranged from 15 to 60 years and both sexes. Serum Zn and Cu levels were measured in each study group
Results: serum Zn levels were statistically significant lower in both the studied groups, but in vitiligo group they were much lower than the control group. Serum Cu levels were statistically insignificant higher in vitiligo group than the control group
Conclusion: there is a relationship between vitiligo and serum Zn. Further studies are needed to obtain better knowledge about effect of the trace elements in vitiligo patients
Résumé
Background: The transversus abdominis plane [TAP] block provide effective postoperative analgesia in lower abdominal surgery. Subcostal TAP block as a new technique to provide analgesia for the supraumbilical abdomen. Traditionally, pain relief for these patients is provided by epidural analgesia or IV opioid analgesia. Although epidural analgesia is currently the "gold standard" for postoperative pain treatment, associated complications and contraindications may limit its use. IV opioid analgesia may cause opioid-related side effects and be associated with inadequate analgesia
Aim of the Work: This study aimed at clinically evaluating and statistically comparing between lumber epidural versus transversus abdominus plane block as postoperative Analgesia for laparoscopic sleeve gastrectomy. Also, our goal was to figure out the most possible effective technique for this kind of procedure with most benefits and least side effects
Patients and Methods: This single blinded randomized clinical trial was carried out at Ain Shams University hospitals on 60 adult Bariatric patients undergoing elective Laparoscopic sleeve Gastrectomy, aged 20 to 50 years, ASA III, BMI equal or less than 45 Kg/m[2]
Results: Patients in the Lumber Epidural group had significantly less pain score when compared to the other TAP group [p-value < 0.001]. And, they had longer time to first request rescue analgesia [nalbuphin] [P = 0.0013]. Also, total dose of nalbuphin consumption was less in Lumber Epidural group than TAP group [P < 0.001]
Conclusion: This study concluded that TAP block was effective in pain relief after Laparoscopic sleeve gastrectomy, however, Lumber Epidural was superior in pain relief, less narcotic consumption and overall more patient satisfaction