Haemagglutination antibody titres & immunoglobulin levels in cases of Plasmodium infection.

Malarial antibody estimation was done in patients with malaria (50), and fever (malaria negative, 50) and in 50 healthy controls who gave no history of malaria for the last one year, using the indirect haemagglutination test (IHA). Seropositivity was 78, 32 and 4 per cent respectively. Levels of IgG and IgM were found to be significantly higher in patients as compared to controls and a significant fall was observed in IgA levels in patients of malaria. Although the malarial antibody titre showed good correlation with IgG (P less than 0.01) and IgM (P less than 0.05) not all patients with a negative haemagglutination antibody titre had normal immunoglobulin levels.