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Int. braz. j. urol ; 44(5): 892-899, Sept.-Oct. 2018. tab, graf
Article Dans Anglais | LILACS | ID: biblio-975631

Résumé

ABSTRACT Purpose: The purpose of our study was to evaluate the clinical impact of 68Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer. Materials and Methods: We retrospectively evaluated 125 prostate cancer patients submitted to the 68Ga-PSMA PET / CT due to biochemical recurrence. The parameters age, Gleason score, PSA levels, and the highest SUVmax were correlated to potential treatment changes. The highest SUVmax values were correlated with age and Gleason score. The median follow-up time was 24 months. Results: 68Ga-PSMA PET / CT led to a treatment change in 66 / 104 (63.4%) patients (twenty-one patients were lost to follow-up). There was a significant change of treatment plan in patients with a higher Gleason score (P = 0.0233), higher SUVmax (p = 0.0306) and higher PSA levels (P < 0.0001; median PSA = 2.55 ng / mL). Conclusion: 68Ga-PSMA PET / CT in prostate cancer patients with biochemical recurrence has a high impact in patient management.


Sujets)
Humains , Mâle , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Oligopeptides , Tumeurs de la prostate/sang , Tumeurs de la prostate/imagerie diagnostique , Acide édétique/analogues et dérivés , Antigène spécifique de la prostate/sang , Tomographie par émission de positons couplée à la tomodensitométrie/méthodes , Récidive tumorale locale/imagerie diagnostique , Tumeurs de la prostate/thérapie , Études rétrospectives , Études de suivi , Sensibilité et spécificité , Grading des tumeurs , Adulte d'âge moyen , Récidive tumorale locale/thérapie
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