Comparison of the epidemiology, profile of mutations, and clinical response to antiretrovirals among subtypes B and F of the human immunodeficiency virus type 1

The authors compared demographic aspects and profile of mutations in 80 patients with subtypes B and F of human immunodeficiency type 1 (HIV-1). Genotyping of the pol region of the reverse transcriptase was performed using the ViroSeqTM Genotyping System. A total of 61 (76.2 percent) patients had subtype B and 19 (23.8 percent) subtype F of the HIV-1. Subtype F tended to be more frequent in heterosexuals and women with a low educational level, but without statistical significance. The frequency of mutations related to nucleoside reverse transcriptase inhibitors and protease inhibitors (PI) was the same in the two subtypes, but mutations related to PI at the codons 63, 77, and 71 were more frequent in subtype B, while mutations at the codons 36 and 20 predominated in subtype F. Sixty-two of the 80 patients infected with subtypes B and F were submitted to antiretroviral therapy for an average of 18-22 months. Undetectable viral loads at the end of follow-up were similar in the two groups, representing 63.8 percent of subtype B and 73.3 percent of subtype F (p = 0.715). CD4 lymphocyte counts before and after treatment were similar in the two groups. This study, despite pointing to possible epidemiological and genetic differences among subtypes B and F of HIV-1, suggests that the use of highly active antiretroviral therapy is equally effective against these subtypes.

Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6 percent) patients. Accessory mutations related to NRTI occurred in 6 (7.1 percent) and related to PI in 67 (79.8 percent). Subtypes B (72.6 percent), F (22.6 percent), B/F 3 (3.6 percent), and C (1.2 percent) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

Tratamento da estrongiloidíase humana e outras parasitoses intestinais com dose única de ivermectina / Treatment of human strongyloidiasis and other intestinal parasitosis with a single dose of ivermectin

Os autores trataram 70 pacientes portadores de estrongiloidíase, ascaríase, tricuríase e ancilostomíase com dose única de ivermectina (200 ug/kg). A cura parasitológica obtida foi de 95 porcento para estrongiloidíase, de 100 poecento para ascaríase e tricuríase e de 60 porcento para ancilostomíase. As reaçöes adversas foram observadas em 3 porcento dos pacientes - cefaléia, náuseas e vômitos.(au)

Protozooses digestivas näo-patogênicas: Revisäo / Intestinal protozoosis not pathogenics: A review

Os autores fazem uma revisäo sobre os protozários digestivos näo-patogênicos, abordando os principais aspectos de sua epidemiologia e clínica

Himenolepíase: atualizaçäo e prevalência no Hospital das Clínicas da UFPE / Hymenolepiasis: a review and prevalence in the \"Hospital das clínicas da Universidade Federal de Pernambuco\", Brazil

Os autores realizaram uma atualizaçäo clínica, laboratorial e terapêutica sobre a himenolepíase e em seguida apresentam sua prevalência no Hospital das Clínicas da UFPE, Brasil

Isosporíase: atualizaçäo / Isosporiasis: review

Os autores fazem uma atualizaçäo sobre isosporíase humana e abordam os principais aspectos da parasitose: epidemiologia, quadro clínico, diagnóstico laboratorial e terapêutica clínica

Parasitoses intestinais na infância: helmintíase / Helminthiasis in childhood

Os autores realizam uma atualizaçäo sobre as principais helmintíases que acometem o trato digestivo humano. Abordam principalmente a sua epidemiologia, ciclo biológico, patogenia, quadro clínico, complicaçöes, diagnóstico e terapêutica, dando ênfase as principais drogas atualmente administradas