Age - related alteration in the pituitary thyroid axis

This study includes 80 persons: 70 elderly subjects above 65 years and 10 healthy middle aged control group [20-40 years of age], both elderly subjects and control group were subjected to the following: Complete history taking, thorough clinical examination with local examination of thyroid gland. The blood samples were taken for estimation of T3, T4 and TSH hormones. There were four elderly subjects proved to be hyperthyroid according to Wayne score class in whom T4 was found raised and within normal TSH and T3. There was three elderly subjects with subclinical hypothyroidism in whom TSH was found high and within normal T3 and T4. There was inverse correlation of TSH with age, but no correlation between T3,T4 with age