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2.
J Vector Borne Dis ; 2006 Dec; 43(4): 161-7
Article Dans Anglais | IMSEAR | ID: sea-118064

Résumé

BACKGROUND & OBJECTIVES: This study was conducted on 50 patients of Anthroponotic cutaneous leishmaniasis (oriental sore) to assess the efficacy of rifampicin and omeprazole through a double blind, randomised placebo control study. METHODS: The diagnosis of Anthroponotic cutaneous leishmaniasis (ACL) caused by Leishmania tropica was done by demonstration of Leishmania tropica (LT) bodies from the painless, dry ulcerative lesion. Each patient was assessed clinically in the beginning of the study, at the end of 2,4 and 6 weeks and all observations were compared in both the groups. Twenty-five patients received rifampicin with omeprazole (Group A) whereas other 25 patients received placebo (Group B) for a period of six weeks. RESULTS: Altogether 23 cases in group Aand 21 cases in group B completed the study. About 16 (69.7%) cases in group A and 3 (14.29%) cases in group B had complete healing, whereas 3 patients (13.04%) of group A and 4 patients (19.05%) of group B had partial response and 4 patients (17.93%) of group A and 14 patients (66.67%) of group B had no response at the end of study. The difference of two groups was statistically highly significant (p < 0.00025). All patients tolerated the drug and placebo very well and no side effect was reported. INTERPRETATION & CONCLUSION: In our opinion rifampicin and omeprazole is a highly effective, less toxic and cheaper alternative for the management of cutaneous leishmaniasis.


Sujets)
Adolescent , Adulte , Sujet âgé , Animaux , Antiprotozoaires/usage thérapeutique , Méthode en double aveugle , Association de médicaments , Femelle , Humains , Leishmania tropica/effets des médicaments et des substances chimiques , Leishmaniose cutanée/traitement médicamenteux , Mâle , Adulte d'âge moyen , Oméprazole/usage thérapeutique , Rifampicine/usage thérapeutique , Résultat thérapeutique
3.
Indian J Dermatol Venereol Leprol ; 2006 May-Jun; 72(3): 224-6
Article Dans Anglais | IMSEAR | ID: sea-52885

Résumé

Protozoan infections of the skin, particularly cutaneous amoebiasis, are rare in HIV-positive patients. We report a case of amoebiasis cutis in an HIV-positive truck driver with a history of frequent unprotected sexual exposures. He presented with multiple painful ulcers and sinuses with purulent discharge, necrotic slough and scarring in the perianal and gluteal region for the last 2 years. He was positive for HIV-1 and -2. Cutaneous biopsy revealed numerous Entamoeba histolytica in the trophozoite form, in addition to an inflammatory infiltrate and necrotic debris. He responded well to oral metronidazole and chloroquine. Amoebiasis cutis should be considered in the differential diagnosis of perianal ulcers, particularly in HIV-positive patients.


Sujets)
Adulte , Amibiase/traitement médicamenteux , Antiamibiens/usage thérapeutique , Animaux , Antiprotozoaires/usage thérapeutique , Maladies de l'anus/traitement médicamenteux , Chloroquine/usage thérapeutique , Entamoeba histolytica/pathogénicité , Infection à Entamoeba/traitement médicamenteux , Humains , Mâle , Métronidazole/usage thérapeutique , Résultat thérapeutique , Ulcère/traitement médicamenteux
4.
Indian J Dermatol Venereol Leprol ; 2002 Sep-Oct; 68(5): 272
Article Dans Anglais | IMSEAR | ID: sea-52325

Résumé

The multiple lesions of cutaneous leishmaniasis (CL) require an effective oral agent. We are reporting a pilot study of oral rifampicin 600 mg. bid or 20 mg/kg. body weight in cases of CL with multiple lesions. Our study shows 83.3% parasitological and clinical cure with insignificant side effects after 4 weeks of therapy. No relapse upto 6 months of completion of study was seen.

5.
Indian J Lepr ; 1990 Oct-Dec; 62(4): 416-21
Article Dans Anglais | IMSEAR | ID: sea-54929

Résumé

26 Patients of leprosy presenting with hypopigmented lesions were divided on morphological grounds into 3 Sub groups, Group I (9 patients) with well-defined single patch with moderate to complete sensory loss; Group II (8 patients) with single ill-defined lesion having partial sensory loss; and Group III (9 patients) having multiple hypo-pigmented patches with mild to moderate sensory loss. Epidermal atrophy was a conspicuous histological finding in all groups. Only patients in Group I showed epitheloid cells in dermal infiltrate with erosion of epidermis in one case. This group may be labelled as maculoanesthetic leprosy. Patients in Group II and III showed mononuclear cell infiltrate in dermis, around neurovascular bundles and appendages. They were histologically consistent with indeterminate leprosy. Follow-up biopsy after six to eight months of treatment showed healing of the lesion of reduction in the infiltrate in most cases.


Sujets)
Adolescent , Adulte , Atrophie , Enfant , Épiderme/anatomopathologie , Femelle , Études de suivi , Humains , Lépromine/diagnostic , Lèpre/anatomopathologie , Lèpre tuberculoïde/anatomopathologie , Mâle , Maladies du système nerveux/anatomopathologie , Troubles de la pigmentation/anatomopathologie , Sensation
6.
J Indian Med Assoc ; 1966 Dec; 47(11): 554-5
Article Dans Anglais | IMSEAR | ID: sea-101955
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