Résumé
In order to assess the use of Astronium urundeuva in folk medicine for treatment of diarrheal conditions, the alcoholic extract of its bark was tested on gastrointestinal transit in mice. The extract at oral doses of 100 and 200 mg/kg significantly inhibited physostigmine-induced gastrointestinal propulsion. Considering these data together with an in-vitro anti-acetylcholine effect reported earlier from this laboratory, we suggest that anti-cholinergic effects of the plant may account in part for its anti-diarrheal activity
Sujets)
Souris , Animaux , Diarrhée/prévention et contrôle , Motilité gastrointestinale/effets des médicaments et des substances chimiques , Extraits de plantes/pharmacologie , Plantes médicinales , Clonidine/pharmacologie , Relation dose-effet des médicaments , Physostigmine/antagonistes et inhibiteursRésumé
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced sodium excretion with no effects on either urine colume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic
Sujets)
Rats , Animaux , Femelle , Inhibiteurs des canaux calciques/pharmacologie , Diurèse/effets des médicaments et des substances chimiques , Hydrochlorothiazide/antagonistes et inhibiteurs , Potassium/urine , Sodium/urineRésumé
The effects of the aqueous extract of Astronium urundeuva Engl. on aspirin and restraint plus hustmine-induced ulceration in rats are described. The extract significantly inhibited aspirin-induced gastric lesions as well restraint plus histamine-induced ulceration in rats