Résumé
Objective@#To explore the value of T2WI and enhanced T1WI magnetic resonance imaging models in differentiating inverted papilloma and polyp of nasal cavity and paranasal sinus．@*Methods@#54 cases of inverted papilloma (NIP) and 51 cases of polyp ( NP) with complete T2WI and enhanced T1WI images confirmed by pathology were collected．ITK snap was used to outline all levels of the lesion．Pyromics was used to extract image omics features．Firstly，the mRMR) was used for feature extraction，and then rfe-SVM was used to remove the feature of minimum score and establish a prediction model．The sensitivity and specificity of ROC curve were used to evaluate the performance of the model，and were verified in the validation set. @*Results@# A total of 1 133 image omics features were extracted，and 30 features were retained after mrmr dimensionality reduction for the establishment of prediction models．The AUC value of T1WI enhanced prediction model was : training set 0. 98，validation set 0. 95，the sensitivity and specificity of training set were 89. 7% and 100% respectively，and the sensitivity and specificity of validation set were 93. 8% and 93. 3% respectively．The AUC value of T2WI prediction model was : training set 0. 95，validation set 0. 91，the sensitivity and specificity of training set were 82. 1% and 95. 6% respectively，and the sensitivity and specificity of validation set were 93. 8% and 84. 2% respectively．@*Conclusion@#MRI based on T1WI enhancement prediction model and T2WI prediction model have certain value in differentiating inverted papilloma and polyp of nasal cavity and paranasal sinus.
Résumé
Objective: To observe the material basis and mechanism of action of Kai-Xin-San (KXS) in regulating antidepression of neurotrophic factors. Methods: KXS eluted by ethanol on macroporous resin was prepared. The antidepressive effect of different components was compared by tailing suspension test and forced swimming test of mice. The levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in hippocampus were determined by ELISA. The rat astrocyte glioma C6 cell line and the rat adrenal pheochromocytoma PC12 cell line were used to evaluate the effects of different ethanol elution sites on the expression of NGF and BDNF and the differentiation of PC12 cells.Results: All of the ethanol elution components from KXS exerted anti-depressive effects by shorting the immobile time of tailing suspension and forced swimming of mice and 70％ ethanol elution components exerted best efficacy. This site also could increase expressions of NGF and BDNF on C6 glioma cell line. The 10％ ethanol elution site had the strongest ability to promote PC12 cell differentiation. Ginsenosides were the main effectuve ingredients for promoting the expression of neurotrophic factors. Conclusion: Regulation of neurotrophic factors might be the prominent action mechanism of KXS exerting anti-depressive effects.