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1.
Kidney Research and Clinical Practice ; : 20-27, 2015.
Article Dans Anglais | WPRIM | ID: wpr-88023

Résumé

BACKGROUND: Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea. METHODS: This study was a multicenter prospective observational study of maintenance HD patients that was performed for 5 years in western Seoul, Korea. Three hundred and sixty-two participants were enrolled. Laboratory values and mortality were accessed every 6 months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. The Hb values were divided into six groups: (1) Hb or =13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hb group, and adjusted for demographics and various laboratory values. Statistics were performed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA). RESULTS: Mortality odds ratios relative to the reference group (10-11 g/dL) in the fully adjusted model were 3.61 for or =13 g/dL (* indicates P<0.05). CONCLUSION: In this study, a Hb level of 10-11 g/dL was associated with the lowest mortality among the groups with Hb level<13 g/dL. Larger interventional trials are warranted to determine the optimal Hb target for Korean HD patients.


Sujets)
Humains , Anémie , Études de cohortes , Démographie , Corée , Mortalité , Étude d'observation , Odds ratio , Études prospectives , Dialyse rénale , Insuffisance rénale chronique , Facteurs de risque , Séoul
2.
The Korean Journal of Internal Medicine ; : 856-864, 2015.
Article Dans Anglais | WPRIM | ID: wpr-195233

Résumé

BACKGROUND/AIMS: To prevent hypocalcemia after parathyroidectomy (PTX), parenteral calcium is required in addition to oral calcitriol and calcium. After switching to oral calcium, patients can be discharged from the hospital. The aim of this study was to analyze the clinical characteristics and outcomes of PTX performed at a single Korean center and to investigate the associated laboratory factors used to analyze the total amount of postoperative calcium required. METHODS: We enrolled 91 hemodialysis patients undergoing PTX from November 2003 to December 2011. We collected clinical and laboratory data preoperatively, 12 and 48 hours postoperatively, at discharge, and 3 and 6 months postoperatively. RESULTS: In total, 59 patients underwent PTX with autotransplantation (AT), 6 underwent total PTX without AT, 11 underwent subtotal PTX, and 15 underwent limited PTX. Total PTX without AT showed the lowest recurrence rate. At all postoperative time points, the mean levels of serum calcium, phosphorus, and intact parathyroid hormone (iPTH) decreased significantly, compared with preoperative levels; however, alkaline phosphatase (ALP) increased significantly from 48 hours postoperatively to discharge (p < 0.001). On multiple linear regression analysis, the total amount of injected calcium during hospitalization showed a significant correlation with preoperative ALP (p < 0.001), preoperative iPTH (p = 0.037), and Deltaphosphorus at 48 hours (p < 0.001). We developed an equation for estimating the total calcium requirement after PTX. CONCLUSIONS: Preoperative ALP, preoperative iPTH, and Deltaphosphorus at 48 hours may be significant factors in estimating the postoperative calcium requirement. The formula for postoperative calcium requirement after PTX may help to predict the duration of postoperative hospitalization.


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Administration par voie intraveineuse , Administration par voie orale , Marqueurs biologiques/sang , Calcium/sang , Carbonate de calcium/administration et posologie , Composés du calcium/administration et posologie , Gluconate de calcium/administration et posologie , Techniques d'aide à la décision , Compléments alimentaires , Hyperparathyroïdie secondaire/sang , Hypocalcémie/diagnostic , Lactates/administration et posologie , Modèles linéaires , Modèles biologiques , Analyse multifactorielle , Hormone parathyroïdienne/sang , Parathyroïdectomie/effets indésirables , Phosphore/sang , Récidive , République de Corée , Études rétrospectives , Facteurs de risque , Facteurs temps , Résultat thérapeutique
3.
Infection and Chemotherapy ; : 359-362, 2011.
Article Dans Coréen | WPRIM | ID: wpr-39115

Résumé

Mycobacterium avium intracellulare complex (MAC) usually causes an opportunistic pulmonary infection in immunocompromised hosts who have underlying structural lung disease. Central nervous system infection due to MAC is very rare even in an immunocompromised host. Most previous reports of central nervous system infection due to MAC have been meningoencephalitis in patients infected with human immunodeficiency virus (HIV). Only four cases of brain abscess due to MAC have been reported worldwide. We report a case of brain abscess due to MAC in a non-HIV patient. Although drugs used for treatment of MAC have limited central nervous penetration, an azithromycin-based anti-tuberculous therapy after surgical drainage of the abscess showed improvement. To the best of our knowledge, this is the first reported case of MAC brain abscess in the Korean literature.


Sujets)
Humains , Abcès , Abcès cérébral , Infections du système nerveux central , Drainage , VIH (Virus de l'Immunodéficience Humaine) , Sujet immunodéprimé , Maladies pulmonaires , Méningoencéphalite , Mycobacterium , Mycobacterium avium
4.
Korean Journal of Gastrointestinal Endoscopy ; : 424-427, 2011.
Article Dans Coréen | WPRIM | ID: wpr-150381

Résumé

Neuroendocrine carcinomas mostly occur in the gastrointestinal tract, lung and pancreas. The gallbladder is an uncommon organ for a neuroendocrine carcinoma and it is difficult to diagnose before gallbladder surgery. Owing to its rare occurrence its natural course and treatment are not definitely established. A 71-year-old woman was hospitalized with intermittent abdominal pain and nausea. Abdominal computed tomography showed multiple masses of the gallbladder obstructing the biliary tract. From endoscopic ultrasonography we suspected carcinoma of the gallbladder that was infiltrating a common bile duct. A biopsy was taken using endoscopic retrograde cholangiopancreatography (ERCP) and the mass was diagnosed as a neuroendocrine carcinoma of the gallbladder. Here we report a case of a neuroendocrine carcinoma of the gallbladder confirmed by endoscopic biopsy, and provide a review of the literature.


Sujets)
Sujet âgé , Femelle , Humains , Douleur abdominale , Voies biliaires , Biopsie , Carcinome neuroendocrine , Cholangiopancréatographie rétrograde endoscopique , Conduit cholédoque , Endoscopie , Endosonographie , Vésicule biliaire , Tube digestif , Poumon , Nausée , Pancréas
5.
Experimental & Molecular Medicine ; : 196-207, 2008.
Article Dans Anglais | WPRIM | ID: wpr-52235

Résumé

We made fusion protein of fastatin and FIII 9-10, termed tetra-cell adhesion molecule (T-CAM) that can interact simultaneously with alphavbeta3 and alpha5beta1 integrins, both playing important roles in tumor angiogenesis. T-CAM can serve as a cell adhesion substrate mediating adhesion and migration of endothelial cells in alphavbeta3 and alpha5beta1 integrin-dependent manner. T-CAM showed pronounced anti-angiogenic activities such as inhibition of endothelial cell tube formation, endothelial cell proliferation, and induction of endothelial cell apoptosis. T-CAM also inhibited angiogenesis and tumor growth in mouse xenograft model. The anti-angiogenic and anti-tumoral activity of molecule like fastatin could be improved by fusing it with integrin-recognizing cell adhesion domain from other distinct proteins. The strategy of combining two distinct anti-angiogenic molecules or cell adhesion domains could facilitate designing improved anticancer agent of therapeutic value.


Sujets)
Animaux , Humains , Mâle , Souris , Inhibiteurs de l'angiogenèse/composition chimique , Antinéoplasiques/composition chimique , Séquence nucléotidique , Benzocaïne/composition chimique , Lignée cellulaire tumorale , Mouvement cellulaire , Prolifération cellulaire , Cellules cultivées , Chloramphénicol/composition chimique , Amorces ADN , Association médicamenteuse , Facteur VIII/composition chimique , Intégrine alpha5bêta1/physiologie , Intégrine alphaVbêta3/physiologie , Souris de lignée BALB C , Nitrofural/composition chimique , Protéines de fusion recombinantes/composition chimique
6.
Experimental & Molecular Medicine ; : 663-672, 2007.
Article Dans Anglais | WPRIM | ID: wpr-170420

Résumé

An extracellular matrix protein plays an important role in skin wound healing. In the present study, we engineered a recombinant protein encompassing the 9th and 10th type III domains of fibronectin, and 4th FAS1 domain of beta ig-h3. This recombinant protein, in total, harbors four known-cell adhesion motifs for integrins: Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) in 9th and 10th type III domains of fibronectin, respectively, and Glu-Pro-Asp-Ile-Met (EPDIM) and Try-His (YH) in 4th FAS1 domain of big-h3, were designated to tetra-cell adhesion motifs (T-CAM). In vitro studies showed T-CAM supporting adhesion, migration and proliferation of different cell types including keratinocytes and fibroblasts. In an animal model of full-thickness skin wound, T-CAM exhibited excellent wound healing effects, superior to both 4th FAS1 domain of beta ig-h3 or 9th and 10th type III domains of fibronectin. Based on these results, T-CAM can be applied where enhancement of cell adhesion, migration and proliferation are desired, and it could be developed into novel wound healing drug.


Sujets)
Animaux , Humains , Souris , Lapins , Motifs d'acides aminés , Adhérence cellulaire/effets des médicaments et des substances chimiques , Lignée cellulaire , Mouvement cellulaire/effets des médicaments et des substances chimiques , Prolifération cellulaire/effets des médicaments et des substances chimiques , Protéines de la matrice extracellulaire/composition chimique , Fibroblastes/cytologie , Fibronectines/composition chimique , Kératinocytes/cytologie , Cellules NIH 3T3 , Protéines de fusion recombinantes/composition chimique , Facteur de croissance transformant bêta/composition chimique , Cicatrisation de plaie/effets des médicaments et des substances chimiques
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