RÉSUMÉ
BACKGROUND: Bupropion SR (sustained-release) is the first non-nicotine-based therapy that is effective for achieving abstinence from smoking. We conducted this clinical trial of bupropion SR for smoking cessation with a seven week follow-up. METHODS: The study subjects involved fifty smokers who had visited the Family Medicine Department at Asan Medical Center from May 2003 to January 2004. Treatment consisted of seven weeks of bupropion 150 mg twice daily. The target day for quitting smoking was day 7. RESULTS: Among 50 subjects who had received bupropion SR, 28 subjects completed the clinical trial and were analyzed. Nineteen subjects were lost to follow up after their first visit. Three subjects discontinued the medication on their own and were lost to follow up after their second visit. According to a telephone interview, 17 subjects out of 22 subjects who were lost failed to feel the need of a revisit for smoking cessation. The rate of abstinence was 26.77% at week 7. The major causes of relapse in smoking were stressful events and anxiety. Only one subject discontinued the treatment attributed to adverse event (nausea). The most common adverse events were insomnia, anxiety, arthralgia, and nausea. We studied to see if the amount of smoking, other smokers in the household, previous attempts to quit, Beck Depression Inventory, and Fagerstrom Tolerance Questionnaire were associated with smoking cessation. However, they failed to show any significant correlation. CONCLUSION: This trial showed that the abstinence rate at the end of 7th week was 25.7% without any serious adverse events.
Sujet(s)
Humains , Anxiété , Arthralgie , Bupropion , Dépression , Caractéristiques familiales , Études de suivi , Entretiens comme sujet , Événements de vie , Perdus de vue , Nausée , Récidive , Troubles de l'endormissement et du maintien du sommeil , Fumée , Fumer , Arrêter de fumer , Enquêtes et questionnairesRÉSUMÉ
Rasmussen's encephalitis is a rare autoimmune disorder characterized by intractable epilepsy and progressive unilateral hemispheric dysfunction as well as mental deterioration. Although the disorder typically begins in childhood, a few cases have been reported with symptom onset in adulthood showing variable clinical characteristics. We report a 63-year-old woman with adult-onset partial seizure with intermittent secondary generalization, progressive right hemiparesis, and aphasia, who showed positive response to high-dose steroid and antiepileptic drugs.