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Journal of Central South University(Medical Sciences) ; (12): 211-214, 2005.
Article Dans Chinois | WPRIM | ID: wpr-813401

Résumé

OBJECTIVE@#To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits.@*METHODS@#Thirty-two New Zealand white rabbits were assigned randomly to the normally feed group, cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group), which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion. Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages.@*RESULTS@#The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group. The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits.@*CONCLUSION@#The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.


Sujets)
Animaux , Mâle , Lapins , Captopril , Pharmacologie , Utilisations thérapeutiques , Endothélines , Sang , Infarctus du myocarde , Sang , Traitement médicamenteux , Lésion de reperfusion myocardique , Myocarde , Monoxyde d'azote , Sang , Répartition aléatoire
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