Role of diffusion weighted MRI in early detection of ischemic cerebrovascular stroke

Is to evaluate the role of diffusion-weighted [DWI] MRI in early diagnosis of ischemic stroke. This study was carried out on one hundred and fifty patients presented with acute focal neurological deficits suggestive of ischemic vascular origin. Brain MRI and diffused weighted images were done to all patients. Brain MRI showed negative results in forty two patients, diffused weighted images were positive in all cases and differentiate multiple age indeterminate ischemic lesions. Also, lesions appeared larger and more conspicuous on DW MRI sequences. Diffusion weighted MRI is superior to the conventional MRI imaging in early detection of ischemic cerebrovascular stroke

Study of human dermal microvasculature after retrograde intravenous pressure infusion [RIPI]

The morphological changes in human dermal microvasculature induced by retrograde intravenous pressure infusion [RIPI] under arterial occlusion of the lower leg [Bier's block] were studied in 18 male subjects, 12 cases with minor foot laceration subjected to RIPI of the antibiotic netilmicin and six served as healthy control volunteers. The ultrastructural study showed a marked dilatation, especially venous capillaries and postcapillary venules with prominent multilayered basal lamina compared with the controls and the pre- technique samples. Lymphatic capillaries were also dilated. The tight junctions between endothelial cells of both dilated blood and lymphatic capillaries were loosened with the appearance of gaps between them. The investigation showed that RIPI of antibiotic into arterially blocked lower limb enhanced the diffusion of molecules into dermis through dermal blood vessels due to a rise of venous blood pressure without any signs of endothelial cell damage which allowed a high local tissue concentration of the antibiotic at the site of injury