IGF-1 and papp-a: early markers of pregnancy complications

Fetal growth is under control of genetic, environmental, and nutritional factors. IGFs and theirreceptors are implicated in the regulation of protein turnover and exert potent mitogenic and differentiating effectson most cell types. Dysregulation of IGF-I actions machinery may contribute to abnormal fetal growth.Pregnancy-associated plasma protein-A [PAPP-A] is produced by the trophoblast; its serum levels increaseduring pregnancy. The level of PAPP-A in maternal serum might reflect the local level of PAPP-A and theavailability of IGFs.In this study, we investigated the role of IGF-1 and PAPP-A in normal and high risk pregnancies, andstudied their levels in relation to pregnancy outcome and complications.Serum levels of both parameters were lower iti high risk groups as compared to low risk pregnant femalesat 11 and 22 weeks gestational age

Comparative study results of treatment of closed femoral shaft fractures using non-reamed interlocking nail versus reamed nail

The controversy about whether to do reamed or nonreamed interlocking nail in the treatment of femoral shaft fractures was the stimulus to do this research work. The material included 20 cases of closed femoral fractures managed at the orthopedic department of Daman-hour National Medical Institute from february/1999 to february/2001,10 cases managed by non reamed interlocking nail and 10 cases managed by reamed interlocking nail with a follow up period[clinically and radiologically at regular interval] at least 1 year post operative .Method of assessment according to the score of Thoresen et al [1985] where excellent and good are satisfactory and fair and poor are un-satisfactory. The results were satisfactory significantly in reamed group, where radiological union was evident earlier, external rotation malunion was less and range of knee motion was better in statistical significant results