Résumé
Objective: Assess immunological relation between atopic disease and Type 1 diabetes mellitus
Subject and Method: Across sectional study was done by written questionnaire adopted from American Academy of Dermatology Journal, [March 2008], from 200 children with Type 1 diabetes mellitus attending pediatric clinic, National Institute of Diabetes, and 200 non diabetic children attending pediatric clinic, New Cairo hospital
Results: Cases had lower frequency of asthma compared to controls with statistically significant difference between both groups, no allergic conjunctivitis among cases was found but was 2% among controls, cases had lower frequency of allergic rhinitis compared to controls with statistically significant difference both groups, and cases had lower frequency of atopic dermatitis compared to controls with no of statistically significant difference between both groups
This study shows no statistically significant difference between both groups as regard type of lactation, effect of food in presence of atopical symptoms, exposure to tobacco smoke. This study shows that cases had lower frequency of interference with daily activities; lower frequency of family history of atopy. This study indicates that positive atopical cases had higher frequency of positive family of atopy compared to negative group with statistically significant difference In between. This study shows that insulin dose among positive atopy cases was lower compared to negative atopy cases group with no significant difference
Conclusion: Patients with Type 1 diabetes have a lower prevalence of atopic symptoms, mainly asthma and allergic rhinitis which is consistent with the Th1/Th2 polarization concept
Additional studies are needed to evaluate the effect of atopy and allergic diseases on glycemic control and long term complications I patients with Type1 diabetes ad to understand why allergic symptoms among children with Type 1 diabetes have decreased
Résumé
Introduction: Adiponectin is a protein hormone secreted exclusive by adipocytes that regulate the metabolism of lipids and glucose. It has antidiabetic, antiatherogenic and anti-inflammatory properties
Objective: To asses adiponectin serum levels in adolescent boys with type development, body mass index [BMI], glycemic control and insulin dosage
Research design and methods: A case-control study was carried out on 45 adolescent boys with T1DM aged [12-18] years and 37 healthy control boys of similar age. Each of the cases and control groups were divided into four subgroups according to their Tanner stage .They were subjected to full history, reviewing medical records, auxology and pubertal stage assessment. Serum total adiponectin level was determined by ELISA technique in addition to giycatedhaemoglobin [HbAlc] and fasting blood glucose
Results: Mean adiponectin serum level [ +/- SD] was significantly higher in T1DM boys compared to healthy control group [12.93 +/- 5.24micro g/mlversus 8.91 +/- 3.21 micro g/ ml] [P<0.001] . Such higher serum levels of adiponectin were detected mainly at Tanner stage 2 [16.571 4.60 micro g/ mlvs 11.88 +/- 3.39 micro g/ ml] [P= 0.025] and Tanner stage 3 [12.77 +/- 3.71 micro g/ ml vs.6.59i 1.54 micro g ml] [P= 0.002]. Adiponectin level decreased significantly during pubertal development in control group and T1DM group. Adiponectin level was significantly higher in diabetic-poor controlled group than diabetic good-controlled group. Adiponectin was negatively correlated with pubertal stage, age, intermediate/ long acting insulin dose and positively correlated to HbAlc in diabetic group. In control group adiponectin levels were negatively correlated with pubertal stage and BMI
Conclusion: Adiponectin serum levels in adolescent boys with type 1 diabetes were significantly higher than control mainly at early puberty. It decreased significantly during pubertal development and was' strongly positively related to glycemic control